dbPTM

ING1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ING1_SCHPO
UniProt AC	O42871
Protein Name	Chromatin modification-related protein png1
Gene Name	png1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	283
Subcellular Localization	Nucleus.
Protein Description	Component of a histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes..
Protein Sequence	MADDTAYILSEYLQTLDNVPNETKHIFDEISVKEVAVHDIWKRIQAADSQIQSYIKSHGSLTPHPKEDALYSTIREEYQKAINIQNEKVQLADRARLGLTRHIKRLDDRLAKAGHGFTAAELLNAPDYYASSPYGGYSPSGASSARQTPAPSRSGASTAGRRRTSATTRGAIQNGVYHSPYTASLADSGSTRGQKVSNATATTQLETKADSTTPNEMVSEEDMEEDNEKYCFCQQGSYGQMVACDNANCEREWFHMECVGLKAPPEGTWYCEACRDQKLVDAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
219	Phosphorylation	TTPNEMVSEEDMEED CCCCCCCCHHHHCCC	33.68	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ING1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ING1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ING1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YNG2_YEAST	YNG2	genetic	20299455
ESA1_SCHPO	mst1	genetic	20299455
ATG11_SCHPO	atg11	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ING1_SCHPO

Related Literatures of Post-Translational Modification