SEC18_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC18_SCHPO
• UniProt AC: Q9P7Q4
• Protein Name: Vesicular-fusion protein sec18
• Gene Name: sec18
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 792
• Subcellular Localization: Cytoplasm.
• Protein Description: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity)..
• Protein Sequence: MDSRWKLPFMSNKGTPEQPMRKPLSGSYSHNSAGPTPNMSPFEQKPPLPTHMDVRRPSGPFRIVKATSTEDALTNCIIVSPMDFKQQYIIVDNSRVFSTKPVPGFPQGCLGASQPHREWASWSLNQQVHVADYDPYGPHGAPYLHSMTLEVDFQNRNRTTNEPFDGEEMAKLFCSSYQSQVFSPGQKIVFDFRSYNIKATVRTISCVDLLIGENQDAENTADTSKRGLLTSQTEIQFFKAAHSALRLKASMTRPASNAILQPGFKFEDMGIGGLDSEFSAIFRRAFASRLFPPGMVEKLGINHVKGILLYGPPGTGKTLIARQIGKMLNAREPKIVNGPEILNKYVGQSEENVRKLFADAEREYRDRGEESGLHIIIFDELDAICKKRGSSGGDTGVGDQVVNQLLAKMDGVDQLNNILVIGMTNRKDMIDEALLRPGRLEVHMEISLPDEHGRLQILKIHTSRMASNGILENDVDMEELASLTKNFSGAEIAGLIKSASSFAFYRHIKVGTTAAVSGNLENIKVNRNDFLNALSEVRPAYGVSEEELESRVQGGIINFGKHIEEIITEGKLFVQQVKNSERTRLVSVLLSGPIASGKTALAATIALGSEFPFVKLVSAESMVGMNENARVAHVNRVFEDSYKSPLSVIVVDEIERIIDWVPIGPRFSNTLLQTLMVLFKKQPPKGHRLLILATTSERTMLSRMDMTQSFDAEIAVPNVSNVTELDRIIQSIDSFADSNVRADTLQRLQNFTGTDAVNVGVAKILMIAETAKQDVDVVSCFVEAMARAIPME

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	HMDVRRPSGPFRIVK CCCCCCCCCCEEEEE	58.23	28889911
250	Phosphorylation	SALRLKASMTRPASN HHHHHHHHCCCCCCC	21.06	24763107
252	Phosphorylation	LRLKASMTRPASNAI HHHHHHCCCCCCCCC	30.88	28889911
256	Phosphorylation	ASMTRPASNAILQPG HHCCCCCCCCCCCCC	29.49	28889911
488	Phosphorylation	ASLTKNFSGAEIAGL HHHHCCCCHHHHHHH	46.62	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC18_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC18_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC18_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RCD1_SCHPO	rcd1	physical	23695164
SEC18_SCHPO	sec18	physical	23695164
ISU1_SCHPO	isu1	physical	23695164
SEC18_SCHPO	sec18	physical	26771498
ISU1_SCHPO	isu1	physical	26771498
MPIP_SCHPO	cdc25	physical	26771498
MSS51_SCHPO	mss51	physical	26771498
RCD1_SCHPO	rcd1	physical	26771498
EI2BB_SCHPO	SPAC343.14c	physical	26771498
ATP11_SCHPO	atp11	physical	26771498
RM09_SCHPO	mrpl9	physical	26771498
ATG11_SCHPO	atg11	physical	26771498
IMA2_SCHPO	imp1	physical	26771498
MU178_SCHPO	mug178	physical	26771498
LAF2_SCHPO	laf2	physical	26771498
SUMT_SCHPO	SPCC1739.06c	physical	26771498
CSL4_SCHPO	csl4	physical	26771498
MMI1_SCHPO	mmi1	physical	26771498
MUG24_SCHPO	mug24	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58 AND THR-252, AND MASSSPECTROMETRY.
PubMed: 18257517