EI2BB_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EI2BB_SCHPO
• UniProt AC: Q9UT76
• Protein Name: Probable translation initiation factor eIF-2B subunit beta
• Gene Name: tif222
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 393
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP..
• Protein Sequence: MSTINVEHTYPAVSSLIADLKSRKVQGPFAVAVETALVMRQVISQTRWSTVDQLIDTVRAVGSTLVKAQPTEFSCGNIIRRILRLIREEYQELLKTADENEKLIVSSSNSSSPSQKRDIPSNEKLVQSHEPVSVQMYSSMLNLLGRPTLESPTHSKTVGDSRVTGGMDMRAVIISGIQDVIDELDKINTDIEVQSMDHLHSNEIILTQGCSKTVEAFLRFAAKKRKFSVIVAEGFPNNQKGSHAMAKRLAQAGIDTTVISDATIFAIMSRVNKVILGTHAILGNGGLVTYSGAQLVAQAARHHATPVVVCSGIYKLSPVYPYDLESIIQLSSPDKIMSFNEGDLISRAEILNPYYDYIPPDLVDLFITNLGGYPPSYLYRIMNDTYDASDTIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	Phosphorylation	ENEKLIVSSSNSSSP CCCCEEEECCCCCCH	22.51	28889911
107	Phosphorylation	NEKLIVSSSNSSSPS CCCEEEECCCCCCHH	23.73	19547744
108	Phosphorylation	EKLIVSSSNSSSPSQ CCEEEECCCCCCHHH	32.97	28889911
110	Phosphorylation	LIVSSSNSSSPSQKR EEEECCCCCCHHHCC	33.85	29996109
111	Phosphorylation	IVSSSNSSSPSQKRD EEECCCCCCHHHCCC	50.98	19547744
112	Phosphorylation	VSSSNSSSPSQKRDI EECCCCCCHHHCCCC	28.52	28889911
114	Phosphorylation	SSNSSSPSQKRDIPS CCCCCCHHHCCCCCC	50.73	25720772
137	Phosphorylation	EPVSVQMYSSMLNLL CCCHHHHHHHHHHHH	4.78	21712547
148	Phosphorylation	LNLLGRPTLESPTHS HHHHCCCCCCCCCCC	41.62	29996109
151	Phosphorylation	LGRPTLESPTHSKTV HCCCCCCCCCCCCCC	37.91	21712547
153	Phosphorylation	RPTLESPTHSKTVGD CCCCCCCCCCCCCCC	48.32	29996109
155	Phosphorylation	TLESPTHSKTVGDSR CCCCCCCCCCCCCCC	32.28	29996109
331	Phosphorylation	LESIIQLSSPDKIMS HHHHHHCCCCCCCCC	24.37	29996109
332	Phosphorylation	ESIIQLSSPDKIMSF HHHHHCCCCCCCCCC	45.79	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EI2BB_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EI2BB_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EI2BB_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MOC3_SCHPO	moc3	physical	26771498
CBH1_SCHPO	cbh1	physical	26771498
YH7G_SCHPO	SPBC16G5.16	physical	26771498
MEU23_SCHPO	meu23	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106; SER-108 ANDSER-112, AND MASS SPECTROMETRY.
PubMed: 18257517