LAF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAF2_SCHPO
• UniProt AC: O74443
• Protein Name: SWIRM domain-containing protein laf2
• Gene Name: laf2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 272
• Subcellular Localization: Nucleus .
• Protein Description: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events..
• Protein Sequence: MQILKDQENLNPDGGSFVLITPPLSPPKQKSLSYTNISRRHGMRACMKGIVYEVYKNQPKLWLQQELIWLRRKRIHPIPKARRNNHVGRWANRHSNVSSSSGSRGRSSVSSRDSSPSYSGALRSAERSISSSPSTIEARRRKSARGNGLNGAIDVANLPFEELPNFCPDMSVLDNRTHPRTLKAEWKGPPLDLSDDPYRDLLHPAELHLASTLRLPCLIYLDNKKRIFAEWHHRRQQGLTFRKTDAQRASRVDVNKASRLWKAFHEVGFFDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GGSFVLITPPLSPPK CCCEEEECCCCCCCC		29996109
25	Phosphorylation	VLITPPLSPPKQKSL EEECCCCCCCCCCCC		25720772
108	Phosphorylation	SGSRGRSSVSSRDSS CCCCCCCCCCCCCCC		25720772
110	Phosphorylation	SRGRSSVSSRDSSPS CCCCCCCCCCCCCCC		25720772
111	Phosphorylation	RGRSSVSSRDSSPSY CCCCCCCCCCCCCCH		25720772
114	Phosphorylation	SSVSSRDSSPSYSGA CCCCCCCCCCCHHHH		29996109
115	Phosphorylation	SVSSRDSSPSYSGAL CCCCCCCCCCHHHHH		28889911
117	Phosphorylation	SSRDSSPSYSGALRS CCCCCCCCHHHHHHH		25720772
128	Phosphorylation	ALRSAERSISSSPST HHHHHHHHHCCCCHH		29996109
130	Phosphorylation	RSAERSISSSPSTIE HHHHHHHCCCCHHHH		28889911
131	Phosphorylation	SAERSISSSPSTIEA HHHHHHCCCCHHHHH		29996109
132	Phosphorylation	AERSISSSPSTIEAR HHHHHCCCCHHHHHH		28889911
135	Phosphorylation	SISSSPSTIEARRRK HHCCCCHHHHHHHHH		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAF2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAF2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of LAF2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.