SIR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIR2_SCHPO
• UniProt AC: O94640
• Protein Name: NAD-dependent histone deacetylase sir2
• Gene Name: sir2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 475
• Subcellular Localization: Nucleus . Chromosome, centromere . Chromosome, telomere . Nuclear throughout the cell cycle. Binds to centromeres, telomeric sites and sites between the silent mating-type loci.
• Protein Description: Involved in silencing within the mating-type region, at the telomeres, and according to PubMed:12867036 also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to PubMed:12867036 to the centromeric DNA regions. According to PubMed:15545655 not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly..
• Protein Sequence: MASNPLDNNMPTTPVEEKIPVASYSPSSSGSSSGASLLVDIMCGSKETEDEEVDSDEWDKPETENISDLDERSEMVRYLRASGYAKFLEKYLIEEELPVRSILKKLGINLPSALEEFEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDLLPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSGELEETDLLICIGTSLKVAPVSELISVIPPTTPQIYISRTPVRHTQFDVNFLSPYCDWVIVEICKRAGWLNELQALCDLPECHSGSKTRAFETDLDIKFEEPSTYHITSTTNGSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PLDNNMPTTPVEEKI CCCCCCCCCCCHHCC	32.72	24763107
13	Phosphorylation	LDNNMPTTPVEEKIP CCCCCCCCCCHHCCC	21.33	21712547
33	Phosphorylation	PSSSGSSSGASLLVD CCCCCCCCCCHHEEE	39.82	27738172
45	Phosphorylation	LVDIMCGSKETEDEE EEEECCCCCCCCCCC	23.53	24763107
48	Phosphorylation	IMCGSKETEDEEVDS ECCCCCCCCCCCCCC	53.09	29996109
55	Phosphorylation	TEDEEVDSDEWDKPE CCCCCCCCCCCCCCC	42.48	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIR2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWI3_SCHPO	swi3	genetic	18818364
CLR3_SCHPO	clr3	genetic	18818364
CID12_SCHPO	cid12	genetic	18818364
YBPD_SCHPO	SPBC16H5.13	genetic	18818364
ASK1_SCHPO	ask1	genetic	18818364
JHD1_SCHPO	epe1	genetic	18818364
YAC5_SCHPO	cph1	genetic	22681890
PAB2_SCHPO	pab2	genetic	22681890
NAA35_SCHPO	mak10	genetic	22681890
ATP14_SCHPO	atp14	genetic	22681890
FFT3_SCHPO	fft3	genetic	22681890
IWR1_SCHPO	iwr1	genetic	22681890
SHF1_SCHPO	shf1	genetic	22681890
MCL1_SCHPO	mcl1	genetic	22681890
CLR3_SCHPO	clr3	genetic	23572080
JHD1_SCHPO	epe1	genetic	24013502
YK82_SCHPO	bdf2	genetic	24013502
YH7G_SCHPO	SPBC16G5.16	physical	26771498
SOL1_SCHPO	sol1	physical	26771498
TAS3_SCHPO	tas3	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND MASSSPECTROMETRY.
PubMed: 18257517