H2A2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2A2_SCHPO
• UniProt AC: P04910
• Protein Name: Histone H2A-beta
• Gene Name: hta2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 131
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling..
• Protein Sequence: MSGGKSGGKAAVAKSAQSRSAKAGLAFPVGRVHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGHVTIAQGGVVPNINAHLLPKQSGKGKPSQEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGGKSGGK ------CCCCCCCHH	57.14	-
5	Acetylation	---MSGGKSGGKAAV ---CCCCCCCHHHHH	49.83	-
9	Acetylation	SGGKSGGKAAVAKSA CCCCCCHHHHHHHHH	36.38	-
20	Phosphorylation	AKSAQSRSAKAGLAF HHHHHHCHHHHCCCC	39.09	25720772
106	Methylation	LGHVTIAQGGVVPNI HCCEEECCCCCCCCC	45.37	24352239
122	Phosphorylation	AHLLPKQSGKGKPSQ EECCCCCCCCCCCCC	48.90	29996109
124	Acetylation	LLPKQSGKGKPSQEL CCCCCCCCCCCCCCC	69.84	21516229
128	Phosphorylation	QSGKGKPSQEL---- CCCCCCCCCCC----	39.51	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H2A2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H2A2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2A2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNA1_SCHPO	rna1	physical	16540522
RHP9_SCHPO	crb2	physical	20679488
CND2_SCHPO	cnd2	physical	21633354
H2B1_SCHPO	htb1	physical	27890612

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks,maintains checkpoint arrest, and influences DNA repair in fissionyeast.";
Nakamura T.M., Du L.-L., Redon C., Russell P.;
Mol. Cell. Biol. 24:6215-6230(2004).
Cited for: FUNCTION, MUTAGENESIS OF SER-128, AND PHOSPHORYLATION AT SER-128.
PubMed: 15226425