| UniProt ID | CTF18_SCHPO | |
|---|---|---|
| UniProt AC | Q9USQ1 | |
| Protein Name | Chromosome transmission fidelity protein 18 | |
| Gene Name | ctf18 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 960 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. Acts as a PCNA loader, loading PCNA onto primed templates. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase.. | |
| Protein Sequence | MDSIPNEDDLEKLLVAEQNVPYGKNYESFEDEENYLLELRNANALENLEHRSIPNDLFHSSQPVGSPTRNGDDIPSTLDLYSSDNAAIDTDISEDETINQRHAPQTDYRYPNTSANPKMGLEESMDIDMPSIDLDISNAAAFPRDSNLLFRNYNSHTKTSEKGSPVNFEKENQDSNVLFSTGRTSVLHIDAEQSQTNNTVTPLKDDALSLFSFENDVNGAVNDNSLDQKLSASKNSQRVSLPFFSKIELDEGSSFSGPKISARTSSGKIIYFPKKKNRHSDGLLLQPKRLADEISQVNEIGKDFNQDLLNSVRIWSENFLIVSKEKSVALKTEKLDSLQITNCTTKPQSQKLWVDTYRPQLFRDLLGDERVHRAAMHWIKAWDPCVFGKSRLQPSKSMRFNPRFTNITSDSDRPDKRIMMLTGLAGAGKTTLAHVIAHQAGYKVLEINASDDRTAHTVHEKVSSAISNHSALSSQPTCVIVDEIDGGDPAFVRALLSLLESDEKATEYSQAGNSKKKKKFKKLCRPIICICNDLYTPALRPLRPYAQIIYFRPPPQASLVGRLRTICRNENIAVDSRSLTLLTDIYNSDIRSCINSLQLLSLNNKRIDSETIKLLQPKSNSFSTSSLIQSLFLQLDNKQIRAIEASQPTYSHLDALLARIDGANDSESVLMNCFHTYLDLPFTDSLLSKPALTSEWLYFFDQLHSQCYKGNYELWRYIPYSIIHFHYLYATPEKCRLPHPPRSDLEALKLYRTRKEILDSFISTLNAYENQMHGERSILLELIRTILITINPTLKQKEDSMPRSALPSKIEHAINILNHYNLRFQQLPVGDGNYVYRLEPPLDELVWDAPTSSYSVRQMLSQELLKKRLADIKKQTLTDNPTSSNSSRKRKDFNSGKAIKRDFFGRIISEPKSEAVTSNNAALNTGDHPVSIKHAINIKFHDGFSNAVRKPISLNEILNF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 28 | Phosphorylation | PYGKNYESFEDEENY CCCCCCCCCCCHHHH | 24.47 | 25720772 | |
| 60 | Phosphorylation | IPNDLFHSSQPVGSP CCCCCCCCCCCCCCC | 24.27 | 25720772 | |
| 61 | Phosphorylation | PNDLFHSSQPVGSPT CCCCCCCCCCCCCCC | 29.90 | 25720772 | |
| 66 | Phosphorylation | HSSQPVGSPTRNGDD CCCCCCCCCCCCCCC | 24.27 | 25720772 | |
| 159 | Phosphorylation | NYNSHTKTSEKGSPV CCCCCCCCCCCCCCC | 43.18 | 29996109 | |
| 160 | Phosphorylation | YNSHTKTSEKGSPVN CCCCCCCCCCCCCCC | 38.58 | 21712547 | |
| 164 | Phosphorylation | TKTSEKGSPVNFEKE CCCCCCCCCCCCCCC | 36.42 | 21712547 | |
| 231 | Phosphorylation | NSLDQKLSASKNSQR CCHHHHHHCCCCCCC | 37.22 | 24763107 | |
| 240 | Phosphorylation | SKNSQRVSLPFFSKI CCCCCCCCCCEEEEE | 32.30 | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTF18_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTF18_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTF18_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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