UniProt ID | RAD21_SCHPO | |
---|---|---|
UniProt AC | P30776 | |
Protein Name | Cohesin subunit rad21 | |
Gene Name | rad21 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 628 | |
Subcellular Localization | Nucleus . Chromosome, centromere . Associates with chromatin. Cohesin complex mainly associates with broad centromere region. Also associates with mating-type heterochromatic region. | |
Protein Description | Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate. Also involved in the DNA double-strand-break (DSB) repair system.. | |
Protein Sequence | MFYSEAILSKKGPLAKVWLAAHWEKKLSKVQTLHTSIEQSVHAIVTEETAPMALRLSGQLMLGVVRIYSRKARYLLEDCTEALMRLKMSFQPGQVDMIEPATALQSLKGKDAVTQSANLTLPETITEFDLLVPDSTFDFQWSQLLRTPSRSSNTLELHSLPISSSPSFPSSQLSIEAGRNAQVESGFSLGESFAHVGNDMQFHLPISNSGAATPRSVHSDNQSQISIEVGRDAPAAAATDLSGIIGPQMTKSPASSVTHFSTPSMLPIGGTSLDDELLAPVDDLNLDLGLDDLLGDEQGANAPAIEADEQAETSSIHLPSDIMEDDSSRPAAAGVEEGQVVESATAPQQEKINPQKTVRRQRAIIDPVTELSSKQMKKQLADTSSITSPLCLNTSSIVFNATVNFTRNGKFNTSIFSSNLNPKVNELLQADFKQAILRKRKNESPEEVEPAKHQRTDTSTENQETAEVLDPEEIAAAELANITEAAIATLPQETVVQPEGEAPELGSPMGFPVTALESADDSLFDAPPVMLDEADLLGSERLDSSVSEALPSSQTAKDSLRNKWDPYTEGEKVSFQTLSAGCNREEAVQLFFDVLVLATKDVISVKQDVAIQNEITLTAKRGMLLSSL | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
164 | Phosphorylation | LHSLPISSSPSFPSS EEECCCCCCCCCCHH | 47.16 | 29996109 | |
165 | Phosphorylation | HSLPISSSPSFPSSQ EECCCCCCCCCCHHH | 20.13 | 29996109 | |
167 | Phosphorylation | LPISSSPSFPSSQLS CCCCCCCCCCHHHEE | 52.30 | 29996109 | |
216 | Phosphorylation | SGAATPRSVHSDNQS CCCCCCCEECCCCCC | 25.94 | 25720772 | |
219 | Phosphorylation | ATPRSVHSDNQSQIS CCCCEECCCCCCCEE | 35.78 | 28889911 | |
242 | Phosphorylation | AAAATDLSGIIGPQM CHHHHCCCCCCCCCC | 30.65 | 29996109 | |
547 | Phosphorylation | ERLDSSVSEALPSSQ CCCCCHHHHHCCCCH | 21.07 | 28889911 | |
552 | Phosphorylation | SVSEALPSSQTAKDS HHHHHCCCCHHHHHH | 35.61 | 28889911 | |
553 | Phosphorylation | VSEALPSSQTAKDSL HHHHCCCCHHHHHHH | 29.61 | 28889911 | |
555 | Phosphorylation | EALPSSQTAKDSLRN HHCCCCHHHHHHHHH | 37.31 | 29996109 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RAD21_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAD21_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAD21_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
RAD22_SCHPO | rad52 | genetic | 166019 | |
SCC4_SCHPO | ssl3 | physical | 16682348 | |
SWI6_SCHPO | swi6 | physical | 11598266 | |
SMC1_SCHPO | psm1 | physical | 11069892 | |
SMC3_SCHPO | psm3 | physical | 11069892 | |
WAPL_SCHPO | wpl1 | physical | 26687354 | |
PDS5_SCHPO | pds5 | physical | 26687354 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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