DEP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DEP1_SCHPO
• UniProt AC: Q9P7M1
• Protein Name: Transcriptional regulatory protein dep1
• Gene Name: dep1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 491
• Subcellular Localization: Nucleus .
• Protein Description: Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity)..
• Protein Sequence: MTENLQSESIPHEILPKEPFDLPMNNLKSSPKNKDSEKRINNSIAESEQVVDSALSNPETNANEDIIAPQLPSQNSEIIEKNSPVNKLNSSTSLTTHQLASLPKLEVTDHDNVSEAETVVLNEDEEKETSLVGSVSVTEDLGDSSAIGRTILVNNSVEPQMENTANITIVSPSLKESDFESEEKATNDNNGLIETNHNSKLEESSEHEEEEDEESNIERTEDSDHQIPQRGGTLEAPRKGGPRSGVGSRKRKRATVSRKWSTNSESKIKRVALETSQEESDREIADRRSASEQAHEADDEKAIKRKEAFDALLNIETEFTFLRNRLYGKKLLKLNEHEEMIQNETHERFNACIDLITERRDDRVRLATENLMKQLGNIKNVMDYVTKQRKYQLLFDKRRIRQALLTKIATKCFQLLNKQKSVHDPTYITQKTMSYRQSALLQKQRIEYEAAVLCELNSFAGFPTAPIIETASFDDIRNDLLEMGCLSENQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	LPMNNLKSSPKNKDS CCCCCCCCCCCCHHH		29996109
30	Phosphorylation	PMNNLKSSPKNKDSE CCCCCCCCCCCHHHH		29996109
83	Phosphorylation	SEIIEKNSPVNKLNS CHHHHHCCCCCCCCC		27738172
108	Phosphorylation	SLPKLEVTDHDNVSE CCCCCEECCCCCCCC		21712547
114	Phosphorylation	VTDHDNVSEAETVVL ECCCCCCCCCEEEEE		21712547
118	Phosphorylation	DNVSEAETVVLNEDE CCCCCCEEEEECCCC		21712547
204	Phosphorylation	HNSKLEESSEHEEEE CCCCCCCCCCCHHHH		28889911
205	Phosphorylation	NSKLEESSEHEEEED CCCCCCCCCCHHHHH		25720772
220	Phosphorylation	EESNIERTEDSDHQI HHHCCCCCCCCCCCC		29996109
223	Phosphorylation	NIERTEDSDHQIPQR CCCCCCCCCCCCCCC		28889911
275	Phosphorylation	IKRVALETSQEESDR HHHHHHHCCHHHHHH		29996109
276	Phosphorylation	KRVALETSQEESDRE HHHHHHCCHHHHHHH		29996109
280	Phosphorylation	LETSQEESDREIADR HHCCHHHHHHHHHHH		29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DEP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DEP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DEP1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of DEP1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.