RIR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIR2_SCHPO
• UniProt AC: P36603
• Protein Name: Ribonucleoside-diphosphate reductase small chain
• Gene Name: suc22
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 391
• Subcellular Localization: Nucleus . Cytoplasm . Localization to the cytoplasm is CSN- and checkpoint-dependent and is required for an efficient DNA damage response.
• Protein Description: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides..
• Protein Sequence: MGLEHLEEFSYPKEHGEEVEYDSEQGVRKIYVKSIKETFNFDNVSEEEKQEGGDYYLGKKEDELDEVVLRPNPHRFVLFPIKYHEIWQFYKKAEASFWTAEEIDLSKDLVDWDNKLNADERYFISTVLAYFAASDGIVNENLLERFSSEVQIPEARCVYGFQIMIENIHSETYSLLLDTYIREPKEKQRHFDAILTMGSIKAKAKWALRWINDEDSTYAIRLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELICRDEGLHTDFACLMFSHLKHRPGRKVVEAIIVEAVDIEKEYFTDALPVSLLGMNKDLMCQYIEFVADRLLVALGNDKYYNVTNPFDFMENISLAGKTNFFEKKVSDYQIAGVMSGTKRAEKDDHTFTIDEDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LEHLEEFSYPKEHGE CHHHHHCCCCHHHCC	43.75	24763107
21	Phosphorylation	EHGEEVEYDSEQGVR HHCCCCEECCCCCCE	29.91	21712547
23	Phosphorylation	GEEVEYDSEQGVRKI CCCCEECCCCCCEEE	30.80	28889911
38	Phosphorylation	YVKSIKETFNFDNVS EEEEHHHHCCCCCCC	20.90	29996109
45	Phosphorylation	TFNFDNVSEEEKQEG HCCCCCCCHHHHHCC	45.61	28889911
364	Phosphorylation	NFFEKKVSDYQIAGV CCEEECCCHHHEEEE	39.21	24763107
375	Phosphorylation	IAGVMSGTKRAEKDD EEEEECCCCCCCCCC	15.28	28889911
384	Phosphorylation	RAEKDDHTFTIDEDF CCCCCCCCEECCCCC	29.48	24763107
386	Phosphorylation	EKDDHTFTIDEDF-- CCCCCCEECCCCC--	28.77	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIR2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPD1_SCHPO	spd1	physical	12695334
RIR1_SCHPO	cdc22	physical	24652833

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.