PUS4_SCHPO - dbPTM
PUS4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUS4_SCHPO
UniProt AC O59721
Protein Name tRNA pseudouridine synthase 4
Gene Name SPBC11C11.10, SPBC3B8.13c
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 407
Subcellular Localization Nucleus . Mitochondrion .
Protein Description Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3'..
Protein Sequence MTVTNTYNPTLFFTRVVFQRITKFTAKANEENEILFYALFVADLCLDMKGGLIAINKPSGRTSAQCLNELKKIISNSELAQYFRPAPPHPNDRNRRRRKSNRLPDIKIGHGGTLDPLASGVLVVGLGTGTKQLSSLLSCMKTYRATALFGCSTDTYDSAGKIIKIAVHIPTKEEILSGLDAFRGDISQLPPLYSALHIQGKRLYEYAREGIPLPESIKARSMHCEELILKDFIPKEEHTYTDPDEFASKEAIESEELLRPIEGGAERHDLLAKTEQDINPQDGDEKINAKSPTTNSVTDVAKDQTVTNPKKRKFEVTDLARGSRPAIGPIAVLDMTVSSGFYVRSLIHDLGRQVNSEAHMVDLVRLKQGSFALDDENCFDFSEFSAPGWEEKLAAAFKIDLKGDETS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
100PhosphorylationRNRRRRKSNRLPDIK
HHHHHHHHCCCCCCC		25.9324763107
291PhosphorylationDEKINAKSPTTNSVT
CCCCCCCCCCCCCHH		25.6828889911
293PhosphorylationKINAKSPTTNSVTDV
CCCCCCCCCCCHHHH		45.7828889911
294PhosphorylationINAKSPTTNSVTDVA
CCCCCCCCCCHHHHH		28.9628889911
296PhosphorylationAKSPTTNSVTDVAKD
CCCCCCCCHHHHHHC		25.0528889911
406PhosphorylationIDLKGDETS------
EECCCCCCC------		44.4728889911
407PhosphorylationDLKGDETS-------
ECCCCCCC-------		35.8625720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUS4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUS4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUS4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YB3C_SCHPOcay1genetic
18818364
ELP1_SCHPOelp1genetic
18818364
ELP6_SCHPOelp6genetic
18818364
ELP4_SCHPOelp4genetic
18818364
CDS1_SCHPOcds1genetic
18818364
MCA1_SCHPOpca1genetic
22681890
ELP6_SCHPOelp6genetic
22681890
PLB2_SCHPOSPAC1A6.03cgenetic
22681890
MTO1_SCHPOSPBC30B4.06cgenetic
22681890
TRM10_SCHPOtrm10genetic
22681890
TRMB_SCHPOtrm8genetic
22681890
YK72_SCHPOSPAC732.02cgenetic
22681890
ELP1_SCHPOelp1genetic
22681890
YAUB_SCHPOSPAC26A3.11genetic
22681890
TRM82_SCHPOSPCC18.13genetic
22681890
RL17B_SCHPOrpl1702genetic
22681890
YGSA_SCHPOdbl8genetic
22681890
CUF2_SCHPOcuf2genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUS4_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291; THR-293; SER-296AND THR-406, AND MASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory