FEP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEP1_SCHPO
• UniProt AC: Q10134
• Protein Name: Iron-sensing transcription factor 1
• Gene Name: fep1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 564
• Subcellular Localization: Nucleus .
• Protein Description: Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3..
• Protein Sequence: MAAKPAPFGQSCSNCHKTTTSLWRRGPDNSLLCNACGLYQKHRKHARPVKSEDLKDISPLIQQVCKNGTCAGDGFCNGTGGSASCTGCPALNNRIRSLNASKSQSGRKSLSPNPSSVPSSTETKASPTPLESKPQIVSDTTTETSNGTSRRRSSHNQHEDSSPPHEPSVTFCQNCATTNTPLWRRDESGNPICNACGLYYKIHGVHRPVTMKKAIIKRRKRLVFNGNANESQHNLKRMSSGDSGSSVKQQSTRDGPFSKSFPNGNGHASGNSGEGLAEHGMNTGVLPPASTFPSYNSNFTGFLPSSFNPSPLMTLSRLAAGEPDNNGKVYYSYGPTQEQSILPLPENKHEGLPPYQNEYVPNGIRANQVVYPGQLVAVGNDSSKQLSESTTSNTDNNGVATANQSNPLGMKFHLPPILPVGESVCLPPRTSAKPRIAEGIASLLNPEEPPSNSDKQPSMSNGPKSEVSPSQSQQAPLIQSSTSPVSLQFPPEVQGSNVDKRNYALNVLSQLRSQHDLMIQELHNLNQHIQQIDEWLRSSDNENMASEHIKSSTPAVVASGALQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	KSQSGRKSLSPNPSS CCCCCCCCCCCCCCC	32.49	28889911
111	Phosphorylation	QSGRKSLSPNPSSVP CCCCCCCCCCCCCCC	29.71	24763107
115	Phosphorylation	KSLSPNPSSVPSSTE CCCCCCCCCCCCCCC	51.08	29996109
116	Phosphorylation	SLSPNPSSVPSSTET CCCCCCCCCCCCCCC	39.03	29996109
119	Phosphorylation	PNPSSVPSSTETKAS CCCCCCCCCCCCCCC	47.97	27738172
126	Phosphorylation	SSTETKASPTPLESK CCCCCCCCCCCCCCC	30.75	29996109
128	Phosphorylation	TETKASPTPLESKPQ CCCCCCCCCCCCCCC	37.70	29996109
132	Phosphorylation	ASPTPLESKPQIVSD CCCCCCCCCCCEEEC	58.27	29996109
231	Phosphorylation	FNGNANESQHNLKRM ECCCCCHHHHHHHHC	36.23	21712547
240	Phosphorylation	HNLKRMSSGDSGSSV HHHHHCCCCCCCCCC	36.96	27738172
470	Phosphorylation	PKSEVSPSQSQQAPL CCHHCCCCHHHCCCC	34.65	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TUP11_SCHPO	tup11	physical	14668334
FEP1_SCHPO	fep1	physical	15866870
GLRX4_SCHPO	grx4	physical	21421748
GLRX4_SCHPO	grx4	physical	21531205
YETB_SCHPO	fra2	physical	24897379
GLRX4_SCHPO	grx4	physical	24897379
GLRX4_SCHPO	grx4	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.
PubMed: 18257517