dbPTM

CLR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLR2_SCHPO
UniProt AC	O13881
Protein Name	Cryptic loci regulator 2
Gene Name	clr2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	537
Subcellular Localization	Nucleus . Chromosome, centromere . Chromosome, telomere . Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Protein Description	Required for deacetylation in the mating-type region and the centromere. Acts upstream of the histone deacetylases to promote transcriptional silencing. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC)..
Protein Sequence	MPAITCVWSDGRSDTWPNVNGHSRTRSVPSLKPLPHQDSKNLLYRQICGRLLAQHVFGGAGSTQPILNQLCKRLSTGNPNNTNASTVVTAPEKNVVSARHVRPNPKSSKDTLEKQPKYSSQIYLTDSFENYYLASLPTNYQLYQRDSNRENGNGKREFWLYGHPSGRPFRSVNDFLHHLYWLISDLTRNESTCCCVLCSGNMTRVRKNLQKENERMFHECKDDTYTWPSSYRLGEVVWIDINNELIPAIIVARNLINYESNQMDAVKLISDTFVEPYQYHCKQLGNSRYYFDMAAADIEPWSRHPLDLQKQEHLVAHSICQTWNLFGIFQPLEGIDMEEPKFHDENYSIPLTVLPTFGGESNSLDDHFYGIFRGAEKLWINDLCVISTSSLPSVLQKTSFMYISDIYVNEDDIVCFQGSLWTQIDKNALDYNDSADNIDEHKDDLKELPRRLQMVSKLSNTYFRCLHDKSVEYVCPFADVLGRWYEPWFVKGDLNYTSEVKERTSSRLSAVGSENWVDDDFYEYLLSEIDMVSAVVM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
434	Phosphorylation	NALDYNDSADNIDEH CCCCCCCCCCCHHHC	33.61	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLR2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JHD1_SCHPO	epe1	genetic	12773576
CLR1_SCHPO	clr1	physical	27105116
CLR3_SCHPO	clr3	physical	27105116

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLR2_SCHPO

Related Literatures of Post-Translational Modification