CLR1_SCHPO - dbPTM
CLR1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLR1_SCHPO
UniProt AC O74808
Protein Name Cryptic loci regulator protein 1
Gene Name clr1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1238
Subcellular Localization Nucleus. Chromosome, centromere. Chromosome, telomere. Associates with major heterochromatin, centromeres, sub-telomeres, rDNA and the mat locus.
Protein Description Regulates silencing of the mat2 and mat3 loci. Organizes the chromatin structure of the mating-type region where it also participates in establishing the 'cold spot' for recombination. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC)..
Protein Sequence MAEPDISSSETLTELQQLRLLYFFCFYHAAPFNVKTLVHSLIPPGALSYLLSTYDILRPWLMALRVREGPVNDISTIVQLYEEIVKTGFFINPPPFESYSQTLVARITTLGRPKLQVQQEAQSEVYQRASTNTQQQVSNVSHGNFKPNSSVNTEPNTSILSNSKYAGIKPFDFQSSSQNPGLVCEQKTFYQHQFRPFSNLPSNKSSPVKHVSPNVKNNSKKTASSVNSNHSSIPSSITKSNISSLDVYGSEKLISSGSQQPGHGMVQTTSDKVNASASLYDRSPSKKDITSSRNTSSYNLGSMRNPSTLKNAAHANPFEGLRFQGSSAVLKEGLNSTVKKTFFDNLNSEKVCPSVSPFLTPDNIASSILYSTASFSRSKPDRPRLNLSLELKLMQNELNKGQLKKQFKGDLRNLADWNNLSLVSSKFPSLPITNLRPDGSFLKHRRFNEEIAYNRQTLEKAIKQLDLSPDKVIQLREQNGVAVNGRVCYPTRNKHSEISAQSSSSLGVTKSLASEVYSSSTVDTISKLNTDKDNYLIKSKKEPIQQKSVSSETTLVKPSSTSSYIDTTNNVLKTNSSFKSSGLTSGPRNEKELLPEGIPTSHNNSETQAQTADVSNIAASADGIYNSDQEKPPEKLDVTKRAFGREIENSNEKELLTSTFLSPSAESQVCLAEIKTIRPGLVPKKQFSVDQNNVISDNTDCSLPKPSNSKLSSISSDGDASSNRMAVPDKSPFVHAAPNSKALTKDSFSTHISVSSLLHSDNEISPIDSTRKDYFTSKDSNLQTLKEDASSTKQAKDSGTNDFDKLISGNDVSKNNSGEEQSRSALKPLISGKLSSCESINLTKDISTVKRKEYFGIESTSSKQPFHDTGSIKIPAKRSFDTIDKDFRSSNIPFADKIKEDGGDKNVISSIHITTELPKSMPVEVPTNAGAQSDQSNVVDSESLNLRENISTSVADVSLSQAGNEAVLSKKACKPLVLIDPFEEKVLKAFNMLSKGYAEYRCQWEGCLANLHSLENFIKHVLLLHHPKSCSVVKCLWASCDMVLPSEEFEMHLRGHLNNIRLNCEVSNCKKCFSNYEDMFKHLQHSHLPFKFTPESFIKIRNGNVKEEARRTRNAYTQKSGEVECFMETCTPIAKPAPANWYPVPPPGFNSSLLSRLTQSNQSKDKIIAALAKRNVYKSFAGLYDSKGKNDNTGYDFDSNYARVGRHGSFILPVSKSVPTPSLLIEGSIVQRKNIKIE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
212PhosphorylationSSPVKHVSPNVKNNS
CCCCCCCCCCCCCCC		15.5224763107
283PhosphorylationSASLYDRSPSKKDIT
CHHHCCCCCCCCCCC		30.5424763107
505PhosphorylationISAQSSSSLGVTKSL
CCCCCCCCCCCCHHH		30.9625720772
509PhosphorylationSSSSLGVTKSLASEV
CCCCCCCCHHHHHHH		17.0825720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLR1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLR1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLR1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
JHD1_SCHPOepe1genetic
12773576
DHE4_SCHPOgdh1genetic
22681890
YCRE_SCHPOtrs130genetic
22681890
AMPD_SCHPOada1genetic
22681890
YAS2_SCHPOcsr102genetic
22681890
YHA8_SCHPOSPBC409.08genetic
22681890
HRP3_SCHPOhrp3genetic
22681890
BQT3_SCHPObqt3genetic
22681890
YHZ8_SCHPOSPBC21B10.08cgenetic
22681890
PPK33_SCHPOppk33genetic
22681890
MU121_SCHPOmug121genetic
22681890
YHG6_SCHPOSPBC1198.06cgenetic
22681890
ADG2_SCHPOadg2genetic
22681890
BDC1_SCHPObdc1genetic
22681890
YQJ9_SCHPOSPCC1840.09genetic
22681890
MFR1_SCHPOmfr1genetic
22681890
AMT1_SCHPOamt1genetic
22681890
PYP1_SCHPOpyp1genetic
22681890
SPN5_SCHPOspn5genetic
22681890
IMA3_SCHPOSPCC550.11genetic
22681890
MU122_SCHPOmug122genetic
22681890
SPN3_SCHPOspn3genetic
22681890
VPS1_SCHPOvps1genetic
22681890
NUP_SCHPOSPCC285.05genetic
22681890
ERG28_SCHPOerg28genetic
22681890
TRK1_SCHPOtrk1genetic
22681890
YN8E_SCHPOSPBP35G2.14genetic
22681890
YAC5_SCHPOcph1genetic
22681890
AP2M_SCHPOapm4genetic
22681890
PLB2_SCHPOSPAC1A6.03cgenetic
22681890
URG3_SCHPOurg3genetic
22681890
TYW2_SCHPOtrm12genetic
22681890
YQ72_SCHPOSPCC1442.02genetic
22681890
FEP1_SCHPOfep1genetic
22681890
YPS1_SCHPOyps1genetic
22681890
PPK8_SCHPOppk8genetic
22681890
WTF21_SCHPOwtf21genetic
22681890
MUG33_SCHPOmug33genetic
22681890
UAF30_SCHPOspp27genetic
22681890
CHP1_SCHPOchp1genetic
22681890
YORQ_SCHPOSPBP8B7.26genetic
22681890
SKB5_SCHPOskb5genetic
22681890
YC1B_SCHPOmsy1genetic
22681890
HOB3_SCHPOhob3genetic
22681890
COM1_SCHPOctp1genetic
22681890
ATF21_SCHPOatf21genetic
22681890
MAD3_SCHPOmad3genetic
22681890
PPR5_SCHPOppr5genetic
22681890
ARP42_SCHPOarp42genetic
22681890
QCR8_SCHPOqcr8genetic
22681890
YBPC_SCHPOSPBC16H5.12cgenetic
22681890
AP3D_SCHPOapl5genetic
22681890
FCF2_SCHPOfcf2genetic
22681890
YJ23_SCHPOSPCC4B3.03cgenetic
22681890
GPA2_SCHPOgpa2genetic
22681890
TPSY_SCHPOSPAC22F8.05genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
JMJ4_SCHPOjmj4genetic
22681890
YBLC_SCHPOSPBC106.12cgenetic
22681890
RLA2_SCHPOrpp201genetic
22681890
YB35_SCHPOSPBC2F12.05cgenetic
22681890
YCF8_SCHPOSPCC1393.08genetic
22681890
PYRD_SCHPOura3genetic
22681890
MBX1_SCHPOmbx1genetic
22681890
YBKD_SCHPOgmh6genetic
22681890
ROK1_SCHPOrok1genetic
22681890
MCP2_SCHPOmcp2genetic
22681890
GLD1_SCHPOgld1genetic
22681890
YBPD_SCHPOSPBC16H5.13genetic
22681890
APE1_SCHPOape2genetic
22681890
SHR3_SCHPOpsh3genetic
22681890
BIOB_SCHPObio2genetic
22681890
MUG94_SCHPOmug94genetic
22681890
MID1_SCHPOmid1genetic
22681890
YG41_SCHPOcxr1genetic
22681890
MPC1_SCHPOmpc1genetic
22681890
YBN5_SCHPOSPBC8E4.05cgenetic
22681890
EMC1_SCHPOemc1genetic
22681890
DOP1_SCHPOSPAPB21F2.02genetic
22681890
RF1M_SCHPOmrf1genetic
22681890
BGL2_SCHPObgl2genetic
22681890
YNT3_SCHPOSPBC9B6.03genetic
22681890
RGA8_SCHPOrga8genetic
22681890
TCG1_SCHPOtcg1genetic
22681890
ULP1_SCHPOulp1genetic
22681890
SEB1_SCHPOseb1physical
24013500
CLR3_SCHPOclr3physical
27105116
MIT1_SCHPOmit1physical
27105116
CLR2_SCHPOclr2physical
27105116
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLR1_SCHPO

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Related Literatures of Post-Translational Modification

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