| UniProt ID | TYW2_SCHPO | |
|---|---|---|
| UniProt AC | Q09832 | |
| Protein Name | tRNA wybutosine-synthesizing protein 2 | |
| Gene Name | trm12 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 418 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity).. | |
| Protein Sequence | MISFLVQKSEAKYWKDVVQNKNKFLKNIGIISGPKLVDTYSNQFEADFLKKCVLIPTSYNKEDLPKDILDCPRIYLIEEEVKSVQTDEKLQIKVLRYVSQILHTTVSEEQYPVPSRFVIYPPLALLSLNSFGTKEWHLFFQSYANVDVKAGLFDIFAREWNVSHIAINEPIPVGDVMRRPLSLKPLYGDFGVLIDGNPSEQDFQKAFWVSCRQNGIYQTWAPLYTMFSRGNSIEKARVLNFSYIKDEIIADLYAGIGYFTFSYVKAGASTVFCWEINPWSVEALRRAALKNGWSIYVVRNGENYEFKVGTHRIVVFLESNVYAAERFSKMNISARHINLGMLPSSEKSWSTATSILKRESHSFIHVHENVKDEDIETYSSEVNSCFSKMLAKNTVCVTNCVKSFSPRVSHIVYDIETV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of TYW2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TYW2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TYW2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TYW2_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SRB11_SCHPO | srb11 | genetic | 18818364 | |
| MPH1L_SCHPO | mph1 | genetic | 22681890 | |
| 6PGL_SCHPO | SPCC16C4.10 | genetic | 22681890 | |
| ERG5_SCHPO | erg5 | genetic | 22681890 | |
| ARP42_SCHPO | arp42 | genetic | 22681890 | |
| YEEB_SCHPO | SPAC19A8.11c | genetic | 22681890 | |
| RL38A_SCHPO | rpl3801 | genetic | 22681890 | |
| SET1_SCHPO | set1 | genetic | 22681890 | |
| CAND1_SCHPO | knd1 | genetic | 22681890 | |
| TOM70_SCHPO | tom70 | genetic | 22681890 | |
| TBA2_SCHPO | atb2 | genetic | 22681890 | |
| CLR1_SCHPO | clr1 | genetic | 22681890 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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