AP2M_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2M_SCHPO
• UniProt AC: Q09718
• Protein Name: AP-2 complex subunit mu
• Gene Name: apm4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 446
• Subcellular Localization: Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane..
• Protein Description: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential)..
• Protein Sequence: MISGLFIFNLKGDTLICKTFRHDLKKSVTEIFRVAILTNTDYRHPIVSIGSSTYIYTKHEDLYVVAITKGNPNVMIVLEFLESLIQDLTHYFGKLNENTVKDNVSFIFELLDEMIDYGIIQTTEPDALARSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWRRAGIKYRKNSIYIDIVERMNLLISSTGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQSESKSKSNNSRNPSSVNGGFVILEDCQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENINIPFRIVPIVEQLSKQKIIYRISIRADYPHKLSSSLNFRIPVPTNVVKANPRVNRGKAGYEPSENIINWKIPRFLGETELIFYAEVELSNTTNQQIWAKPPISLDFNILMFTSSGLHVQYLRVSEPSNSKYKSIKWVRYSTRAGTCEIRI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
145	Phosphorylation	KKKGNALSLKRSHSS EECCCEEEEECCCCC	29.45	28889911
149	Phosphorylation	NALSLKRSHSSQLAH CEEEEECCCCCCCCC	26.57	25720772
151	Phosphorylation	LSLKRSHSSQLAHTT EEEECCCCCCCCCCC	22.49	28889911
152	Phosphorylation	SLKRSHSSQLAHTTS EEECCCCCCCCCCCC	24.64	28889911
157	Phosphorylation	HSSQLAHTTSSEIPG CCCCCCCCCCCCCCC	23.83	28889911
292	Phosphorylation	VELMSYRSHENINIP EEEEEEECCCCCCCC	27.24	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AP2M_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2M_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2M_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of AP2M_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-145; SER-151; SER-152AND THR-157, AND MASS SPECTROMETRY.
PubMed: 18257517