SEB1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEB1_SCHPO
• UniProt AC: Q9UTE3
• Protein Name: Rpb7-binding protein seb1
• Gene Name: seb1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 620
• Subcellular Localization: Nucleus .
• Protein Description: Involved in the processing of pol II transcripts..
• Protein Sequence: MSGIAEFDGILDSLEHSKTGISGSKILKLTNLSMENVSENAQFVASVYKYAKRAPVTHKLGALYILDSIVRSFQDGAKKNNESFENPVDASFSGGWCKAAEITDSLVADAIQHAPSAHLPKILKLCDIWEKASTFPPEKLESLRSKLKDAMASTEPVSVDSAAAPSQSTNPEGNGGSVGSQAAAPTSRPVENDAASILEALAAFAQKAPVPSAAEESVSTPPQPAVAPSVSAVVPNLPVHPATAINAQSQSGNPLSNPLFQPSNVPQSIPSGPMGMKTGSVNDTQSQQITLMNVLASQNVPPAQIDSIMKAAFPNYNAPFQPAGVGSVPLPAPTSSQSLRLGSLHRSRSPSPRSGRPRRSPSPSHLSIPSTLPPADGVPKPTPDGFPRRFERDPTIPPDSIKVYSRTLFLGGITRSVREPVLRSMFERFGSVQSLILNHNYRHGFLKMFRRDAAEKAQVAMENVPFADTTIRTKWGVGFGPRECSDFSTGISVIPIRLLTDADRTWLVTAEYGGTGGLPITPGIALDEPDIEIGLGISSKAISKRGKDFAMRRDERFRGRKPYRGGPPIHHGERHFDSGNDWHGNPSTVPPPTNPYNPGYPYMDPNYSSGYVSQPPWQPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
335	Phosphorylation	VPLPAPTSSQSLRLG CCCCCCCCCCCEECC	25.89	27738172
343	Phosphorylation	SQSLRLGSLHRSRSP CCCEECCCCCCCCCC	26.12	28889911
347	Phosphorylation	RLGSLHRSRSPSPRS ECCCCCCCCCCCCCC	26.77	25720772
349	Phosphorylation	GSLHRSRSPSPRSGR CCCCCCCCCCCCCCC	30.86	25720772
351	Phosphorylation	LHRSRSPSPRSGRPR CCCCCCCCCCCCCCC	33.90	25720772
360	Phosphorylation	RSGRPRRSPSPSHLS CCCCCCCCCCCCCCC	30.89	25720772
362	Phosphorylation	GRPRRSPSPSHLSIP CCCCCCCCCCCCCCC	40.04	25720772
364	Phosphorylation	PRRSPSPSHLSIPST CCCCCCCCCCCCCCC	41.20	29996109
367	Phosphorylation	SPSPSHLSIPSTLPP CCCCCCCCCCCCCCC	27.34	29996109
370	Phosphorylation	PSHLSIPSTLPPADG CCCCCCCCCCCCCCC	40.69	29996109
371	Phosphorylation	SHLSIPSTLPPADGV CCCCCCCCCCCCCCC	37.62	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEB1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEB1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEB1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPB7_SCHPO	rpb7	physical	12907709
CLR3_SCHPO	clr3	physical	24013500
CLR1_SCHPO	clr1	physical	24013500
MIT1_SCHPO	mit1	physical	24013500
PABP_SCHPO	pabp	physical	28367989
RNA14_SCHPO	rna14	physical	28367989
CFT1_SCHPO	cft1	physical	28367989
CFT2_SCHPO	cft2	physical	28367989
YSH1_SCHPO	ysh1	physical	28367989
PTA1_SCHPO	pta1	physical	28367989
PFS2_SCHPO	pfs2	physical	28367989
YTH1_SCHPO	yth1	physical	28367989
FIP1_SCHPO	fip1	physical	28367989
YJ03_SCHPO	rhn1	physical	28367989
RPB1_SCHPO	rpb1	physical	28367989
XRN2_SCHPO	dhp1	genetic	28367989
PFS2_SCHPO	pfs2	genetic	28367989

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, AND MASSSPECTROMETRY.
PubMed: 18257517