CFT2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CFT2_SCHPO
• UniProt AC: O74740
• Protein Name: Cleavage factor two protein 2
• Gene Name: cft2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 797
• Subcellular Localization: Nucleus .
• Protein Description: RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes (By similarity)..
• Protein Sequence: MLNYQCLETDSYCGTSHIELDGIHIYIDPGSDDSLKHPEVPEQPDLILLSHSDLAHIGGLVYAYYKYDWKNAYIYATLPTINMGRMTMLDAIKSNYISDMSKADVDAVFDSIIPLRYQQPTLLLGKCSGLTITAYNAGHTLGGTLWSLIKESESVLYAVDWNHSKDKHLNGAALYSNGHILEALNRPNTLITDANNSLVSIPSRKKRDEAFIESVMSSLLKGGTVLLPVDAASRVLELCCILDNHWSASQPPLPFPILFLSPTSTKTIDYAKSMIEWMGDNIVRDFGINENLLEFRNINTITDFSQISHIGPGPKVILATALTLECGFSQRILLDLMSENSNDLILFTQRSRCPQNSLANQFIRYWERASKKKRDIPHPVGLYAEQAVKIKTKEPLEGEELRSYQELEFSKRNKDAEDTALEFRNRTILDEDLSSSSSSEDDDLDLNTEVPHVALGSSAFLMGKSFDLNLRDPAVQALHTKYKMFPYIEKRRRIDEYGEIIKHQDFSMINEPANTLELENDSDDNALSNSNGKRKWSEINDGLQQKKEEEDEDEVPSKIITDEKTIRVSCQVQFIDIEGLHDGRSLKTIIPQVNPRRLVLIHASTEEKEDMKKTCASLSAFTKDVYIPNYGEIINVSIDVNAFSLKLADDLIKNLIWTKVGNCEVSHMLAKVEISKPSEEEDKKEEVEKKDGDKERNEEKKEEKETLPVLNALTLRSDLARAPRAAPLLVGNIRLAYLRKALLDQGISAELKGEGVLLCGGAVAVRKLSGGKISVEGSLSNRFFEIRKLVYDALAVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
515	Phosphorylation	MINEPANTLELENDS CCCCCCCEEEECCCC	24.58	21712547
522	Phosphorylation	TLELENDSDDNALSN EEEECCCCCCCCCCC	59.45	21712547
528	Phosphorylation	DSDDNALSNSNGKRK CCCCCCCCCCCCCCC	35.48	27738172
530	Phosphorylation	DDNALSNSNGKRKWS CCCCCCCCCCCCCHH	43.51	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CFT2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CFT2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CFT2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of CFT2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.