XRN2_SCHPO - dbPTM
XRN2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID XRN2_SCHPO
UniProt AC P40848
Protein Name 5'-3' exoribonuclease 2
Gene Name dhp1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 991
Subcellular Localization Nucleus.
Protein Description Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation. Possesses 5'->3' exoribonuclease activity..
Protein Sequence MGVPALFRLLSRKFAKVITPVIEAPTEKLPDGTEIEPDLSLPNPNGVECDNLYLDMNGIVHPCSHPEDRPAPETEDEMMVAVFEYTDRILAMVRPRQLLFIAIDGVAPRAKMNQQRSRRFRSSREAALKEEELQAFIEEAKQQGIPIDENATKKKSWDSNCITPGTPFMDTLAKSLRYYIINKLNSDPCWRNVRFILSDASVPGEGEHKIMEFIRSQRVKPEYDPNTHHVVYGLDADLIMLGLATHEPHFRVLREDVFFQQGSTKKTKEERLGIKRLDDVSETNKVPVKKPFIWLNVSILREYLEVELYVPNLPFPFDLERAIDDWVFFIFFVGNDFLPHLPSLDIRDGAVERLTEIWRASLPHMGGYLTLDGSVNLARAEVILSAVGNQEDDIFKRLKQQEDRRNENYRRRQQRESNQESESYVDNVVIQRSVETQSTEVVTSSKSTSVDTKPPKKTQKIDAPAPVDLVNLSEKTSNRSLGATNRELINNRAANRLGLSREAAAVSSVNKLAASALKAQLVSNETLQNVPLEDSIASSSAYEDTDSIESSTPVVHPIDTKVSNVGQKRKAPDSTEENENTDTVRLYEPGYRERYYEQKFHISPDEPEKIREAVKHYVHGLCWVLLYYYQGCPSWTWYYPYHYAPFAADFKDLASIDVKFELNQPFKPYEQLLGVLPAASKNNLPEKLQTLMTDENSEIIDFYPENFTIDLNGKKFEWQGVALLPFIDENRLLNAVSKIYPQLTEEESKRNEDGSTLLFISEHHPMFSELVKQLYSKKRQGKPLKLSGKMAHGLFGKVNTNDSVIPNVSVQCPIDVTSADALQKYGSIDDNQSISLVFEVPKSHFVHKSMLLRGVKMPNRVLTPEDINQVRAERSFSSRRNNGNSYRGGHQSYGVRRSYQSQSYSSRQSYTGVTNGFANGGVQPPWSGNGNFPRSNASYNSRGGHEGYGGRSRGGGYSNGPPAGNHYSSNRGKGYGYQRESYNNNNRNGYY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
421PhosphorylationQRESNQESESYVDNV
HHHHHHHCHHHHHCE		23.2925720772
423PhosphorylationESNQESESYVDNVVI
HHHHHCHHHHHCEEE		39.4725720772
424PhosphorylationSNQESESYVDNVVIQ
HHHHCHHHHHCEEEE		14.0525720772
574PhosphorylationQKRKAPDSTEENENT
CCCCCCCCCCCCCCC		36.3425720772
737PhosphorylationNRLLNAVSKIYPQLT
HHHHHHHHHHHHHCC		15.7829996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of XRN2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of XRN2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of XRN2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DXO_SCHPOdin1genetic
11238999
AGO1_SCHPOago1genetic
26631744
DXO_SCHPOdin1physical
26631744
PAB2_SCHPOpab2physical
26631744
MMS19_SCHPOmms19physical
26631744
NRDE2_SCHPOnrl1physical
26631744
RIK1_SCHPOrik1physical
26631744
CHP2_SCHPOchp2physical
26631744
RRP6_SCHPOrrp6physical
26631744
HRR1_SCHPOhrr1physical
26631744
RDP1_SCHPOrdp1physical
26631744
MMI1_SCHPOmmi1physical
26631744
RAF2_SCHPOraf2physical
26631744
AGO1_SCHPOago1genetic
26889830
DCR1_SCHPOdcr1genetic
26889830
RRP6_SCHPOrrp6genetic
26889830
CLR3_SCHPOclr3genetic
26889830
SIR2_SCHPOsir2genetic
26889830
RPB7_SCHPOrpb7genetic
26889830
RPB2_SCHPOrpb2genetic
26889830
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of XRN2_SCHPO

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Related Literatures of Post-Translational Modification

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