dbPTM

CHP2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHP2_SCHPO
UniProt AC	O42934
Protein Name	Chromo domain-containing protein 2
Gene Name	chp2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	380
Subcellular Localization	Nucleus.
Protein Description	Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation..
Protein Sequence	MVKSADLDLMNSIISESDENFSPPPFTVEEAENSINNKSSTASLESPQNGSWHPSLYGLSVPEKTHIQNSLDLYSHGNSGSQKTHNVSFSCEIRKVKSSKLSPISNMEDSEDKKEEDESSSYKNEFKSSSSASVSSNFEKTSGSDDHNSQSPVPLNEGFEYIASSGSEDKNSDEEFAVEMILDSRMKKDGSGFQYYLKWEGYDDPSDNTWNDEEDCAGCLELIDAYWESRGGKPDLSSLIRLTRSRARSSNEASYVEKDESSNSDDSISYKRRRSRNAANRITDYVDSDLSESSMKEKQSKIEKYMKSDKSSKNFKPPFQKKSWEDLVDCVKTVQQLDNGKLIAKIKWKNGYVSTHDNIIIHQKCPLKIIEYYEAHIKFT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
198	Sumoylation	SGFQYYLKWEGYDDP CCCEEEEEECCCCCC	27.38	-
249	Phosphorylation	LTRSRARSSNEASYV HHHHHHCCCCCCCCE	36.21	29996109
250	Phosphorylation	TRSRARSSNEASYVE HHHHHCCCCCCCCEE	32.89	29996109
288	Phosphorylation	RITDYVDSDLSESSM HHHHHHCCCCCHHHH	30.33	25720772
291	Phosphorylation	DYVDSDLSESSMKEK HHHCCCCCHHHHHHH	40.18	25720772
293	Phosphorylation	VDSDLSESSMKEKQS HCCCCCHHHHHHHHH	32.15	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHP2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHP2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHP2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLR4_SCHPO	clr4	physical	15372076
CLR3_SCHPO	clr3	genetic	18809570
SEB1_SCHPO	seb1	physical	24013500

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHP2_SCHPO

Related Literatures of Post-Translational Modification