RRP6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP6_SCHPO
• UniProt AC: Q10146
• Protein Name: Exosome complex exonuclease rrp6
• Gene Name: rrp6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 777
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. RRP6 has 3'-5' exonuclease activity which is not modulated upon association with Exo-9 suggesting that the complex inner RNA-binding path is not used to access its active site (By similarity)..
• Protein Sequence: MDESELFKGLMNSTAYCSELAKVDIPFYKSIDTEFNENIKSVSSRFMRLIELLLSKVDRSRAEDIVDVEDIDNRWAEVSDTLDILFEKADYSIDKAQGLLKKPAIETHASTSDVANKKPKKEKLPYKVIHAAHLTKPQLRFRVQPNNSREFVWSWKLTEKPHSLVPLEKIIAQVKLDPSLKNSLPHPYEPEIQNSVYPPWVSEMSNPIDTGSVDETEPIWVSTESQLSDMLKELQNSKEIAVDLEHHDYRSFRGFVCLMQISNREKDWIVDTLELREELEALNVVFTNPNIIKVFHGATMDIIWLQRDFGLYVVNLFDTYYATKVLGFEGHGLAFLLQKYCDYDADKRYQMADWRIRPLPREMLKYAQSDTHYLLYIWDHLRNELISKSAERKENLMQSVFNSSKQISLRKYELEPYDPIYGLGTDGWRNVLTKFGSSKIIGREALMIYRALHDWRDSVARKEDESVRYVLPNRLLIAIAASKPVEAADVFSISKQLTPIARMYVEDIVKVVQEAEKLYNEQVDREKSQFKEVEKQNQPLAVFSESNTLGDYKVDSSVFEISKQNRSKLKTLLANGSAFWIEGQSQDDLRKARKERLFIVNQNIPFSLTLPCTQGHVESELNVKQSTVTEAANPSLNGEKKQEPIVIRDLGLNKQKRDSSKLNHKEPSNPIEERNEDIEPSEASTSVSKKRKQKKKKKNSGKLTIEAEHVSNDSPIINEAPFDYKNQKNFIADLDSDVGKNKFGKRGFNPLNKVSLPKRNTRELKKRKVSDGKSTSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
704	Phosphorylation	KKNSGKLTIEAEHVS CCCCCCCEEEEEECC	21.91	24763107
736	Phosphorylation	NFIADLDSDVGKNKF CEEECCCCCCCCCCC	41.30	21712547
770	Phosphorylation	ELKKRKVSDGKSTSY HHHHCCCCCCCCCCC	43.62	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAB2_SCHPO	pab2	physical	20129053
PAB2_SCHPO	pab2	genetic	20129053
PAP_SCHPO	pla1	genetic	20512112
MMI1_SCHPO	mmi1	genetic	20512112
YLP3_SCHPO	red1	physical	21317872
MMI1_SCHPO	mmi1	genetic	22046364
AGO1_SCHPO	ago1	genetic	23151475
DCR1_SCHPO	dcr1	genetic	23151475
CLR4_SCHPO	clr4	genetic	23151475
RDP1_SCHPO	rdp1	genetic	23151475
YLP3_SCHPO	red1	genetic	23151475
PAB2_SCHPO	pab2	genetic	23151475
PAP_SCHPO	pla1	genetic	23151475
YGS9_SCHPO	tri1	genetic	24095277
DCR1_SCHPO	dcr1	genetic	24095277
CLR4_SCHPO	clr4	genetic	24493644
YLP3_SCHPO	red1	physical	24713849
YE02_SCHPO	mtl1	physical	24713849
CLR4_SCHPO	clr4	genetic	24210919
XRN2_SCHPO	dhp1	genetic	26631744

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.