DOP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOP1_SCHPO
• UniProt AC: Q9C0Z4
• Protein Name: Protein dopey
• Gene Name: SPAPB21F2.02
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1687
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein. Late Golgi..
• Protein Description: Involved in cellular morphogenesis. Required for traffic between late Golgi and early endosomes, and for the normal structure and organization of the endoplasmic reticulum (By similarity)..
• Protein Sequence: MNTIIDASNDAKYRKYQDAIRKCIALFQTVEQWPDYISFLTKLHKVLQTHSSFVNIPCSLLVSRALAECLSPGLPSGVHKKTLEVYDYIFTIIGSKTLTNELSTWSYGLTPFFSISSIKTKHDYINIIKKHYVSLGVGIRPCFQAVFISLLSGLEEDVDESSQEVYHLLDDLVKVLNDEKFAWGCIWSTILSFPSQRPGALAYLLRVCNNLAEEDIQTRVIQPDSGLVVRSFAAAISDNDILVQRGYMDALLNYFPIQSTFYKDVKPFDLKLLHMSVASIVLRNDLSLNRRFYAWLMGLSKDTELSISDSSITVDENTLQQNMAIFFEGVKDLLSSKNSLMSFYKAFRILYALSDRRPLFTIVESQILPCVLHSYETLTNVFHRDDSKHLYESAVDHGRRLIMKFSDSELHTFLFHCVNKIVANTTENSDSAEAVKFILDSQNFFFESINTEYSFIIFTNLLMHLEKTSPNSDVDGVSMTILTICKILLNNFDWNFFNYNNSAIDSYAKCTLNLDSDFENGILTYEILYKKCKCSLLSLLKQYIKDSHVHHEVLLISLNLIKEASDTEFENEFLDLSLQGFKDNSWSFQTLGSFVKQLPSRILINSTACVNVILDRIWCELCMFSYFREEELLSVIWTLQEKLQTRIIESYFSTCIVKEQLELRAPTIYYTPFYNLLKKSAQQSLFHFVFDRPLLLLLNSLLEDESGRDYTAMMNWINASSSLQLRVLELMTENLLSLSPNLTSVNSLETAMTRYNINEDQRNSEASRCVYFLKLCTRIISYFQDLHPKEGRLKSAKQVEELCLVTWADALLIQKKSLTYSSFLAFLVKLCLDIVLTPQNIKTSTDVYIIQTWALRLLYQITSIWENPLKFESSLIVGLFALVQEVERSPSSTYRSFILSLLQMLEFLLSRLDGTIDLSSEQHYLLSNFVLVGMLNDDPGLSPKWLHAIKKLLPLLLQNLQLLMVNPIQSLCKFVHSFLDQHESMYLKYPDPVKDYACMDVFIAKLKMLSELVSAALLEFTYSPGPKKSNLEANGIIGNVISGVFAAESSGVSIDVNKRLSMLLTMQDALQTLFLSYSWHIRSSYADKTSKVFMNDSSVLKEASLSGLKEFYFCEPLECVETLVQIYLENNVECCQCIWDIFSFLSDSEPQYIVKQLVSSFFAREGIASYAGPSSLTAKITQLDILCCMSDFVSRVEGENTSKIFTEISKFVREIISSSNSFKNYLLVCLRMLLEVAKNVNTYCESRQQKDFIDLMGKTLSSVLFHAGKSSDPNLTVDFLAYHKAAADTFEVAKTQKKTSSVYLFVKYLDPSLLDFFCSEFVPKITELSKEEDKLVAWATSIVNVFITPLVKARTFPESLTTYHLDLLLVLSKHPFLSKSWRRDFWEIFNDNSLFRFDIDQLRKLSPVIYTALYQEISRLNDLITKSDLGVTTLFTSRDTQLGARQSNICRITILMLSSPRDFFLPSLPPLIDLVKRLITSDPEGVLKKDLFLFIRALALRTSSKHLLPLWPIVVSELLIIFKSYCMPNVAISKETLLDACRLLDFLTALKLEEFALHEWVVMLSPLDAVYWSGKTSRKSLVQKVSERLQEQASEKDDKSSVESEHSILTSTTRTPSLGIYTTDAQLRNFLNRISIDAYEESYSFSTIDIQSFENSIYREVLQRFSNAPLSPFSSIKAPSSLAGSSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1594	Phosphorylation	ERLQEQASEKDDKSS HHHHHHHHHCCCCHH	44.89	24763107
1600	Phosphorylation	ASEKDDKSSVESEHS HHHCCCCHHHHHHHH	46.76	29996109
1601	Phosphorylation	SEKDDKSSVESEHSI HHCCCCHHHHHHHHH	35.33	25720772
1604	Phosphorylation	DDKSSVESEHSILTS CCCHHHHHHHHHHCC	38.15	29996109
1607	Phosphorylation	SSVESEHSILTSTTR HHHHHHHHHHCCCCC	18.42	25720772
1671	Phosphorylation	RFSNAPLSPFSSIKA HHCCCCCCCCCCCCC	23.88	28889911
1674	Phosphorylation	NAPLSPFSSIKAPSS CCCCCCCCCCCCCHH	34.24	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOP1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of DOP1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1671, AND MASSSPECTROMETRY.
PubMed: 18257517