UBX2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBX2_SCHPO
• UniProt AC: O14048
• Protein Name: UBX domain-containing protein 2
• Gene Name: ubx2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 427
• Protein Description: Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway..
• Protein Sequence: MDGDEASLVANFCAITNSTPEKAQEYLSVADGDLSTAITLFFESGGVTDVQSSYIEAPSQTEPVEEIRAPIAPTREVLVDPLADMSAGTSIMGNNFGFGGFPRMNRRQRRRMGIFDQSPSQIPFPSSNTEDSSEESDSSSRASRLAKLFRPPYDIISNLSLDEARIEASSQKRWILVNLQTSTSFECQVLNRDLWKDESVKEVIRAHFLFLQLLDDEEPGMEFKRFYPVRSTPHIAILDPRTGERVKEWSKSFTPADFVIALNDFLEGCTLDETSGRKNPLGAKSQKPVEAMSEDEQMHKAIAASLGNGNSTTESQGESSSQQAESHGVADDTVHKIDSAECDAEEPSPGPNVTRIQIRMPNGARFIRRFSLTDPVSKVYAYVKGVAEGADKQPFSLTFQRKSLWTSLDSTIKEAGIQNTALQFEFQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
127	Phosphorylation	SQIPFPSSNTEDSSE CCCCCCCCCCCCCCC	48.27	25720772
129	Phosphorylation	IPFPSSNTEDSSEES CCCCCCCCCCCCCCC	43.02	25720772
132	Phosphorylation	PSSNTEDSSEESDSS CCCCCCCCCCCCCCC	33.16	25720772
133	Phosphorylation	SSNTEDSSEESDSSS CCCCCCCCCCCCCCH	58.67	25720772
136	Phosphorylation	TEDSSEESDSSSRAS CCCCCCCCCCCHHHH	38.45	25720772
138	Phosphorylation	DSSEESDSSSRASRL CCCCCCCCCHHHHHH	39.22	27738172
285	Phosphorylation	KNPLGAKSQKPVEAM CCCCCCCCCCCCHHC	42.79	21712547
293	Phosphorylation	QKPVEAMSEDEQMHK CCCCHHCCHHHHHHH	49.28	24763107
320	Phosphorylation	TESQGESSSQQAESH CCCCCCCHHHHHHHC	28.06	27738172
321	Phosphorylation	ESQGESSSQQAESHG CCCCCCHHHHHHHCC	35.27	27738172
371	Phosphorylation	ARFIRRFSLTDPVSK CEEEEEEECCCCHHH	28.66	28889911
373	Phosphorylation	FIRRFSLTDPVSKVY EEEEEECCCCHHHHH	36.74	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBX2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBX2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBX2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC48_SCHPO	cdc48	physical	15120077
UBX3_SCHPO	ubx3	physical	23695164
UBX2_SCHPO	ubx2	physical	23695164
UBX2_SCHPO	ubx2	physical	26771498
UBX3_SCHPO	ubx3	physical	26771498
YH73_SCHPO	SPBC16G5.03	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-371, AND MASSSPECTROMETRY.
PubMed: 18257517