CDC48_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC48_SCHPO
• UniProt AC: Q9P3A7
• Protein Name: Cell division cycle protein 48 {ECO:0000250|UniProtKB:P25694}
• Gene Name: cdc48 {ECO:0000250|UniProtKB:P25694}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 815
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Cdc48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel..
• Protein Sequence: MNAPSTMTDKKPEVEHLQGENPPKDTYSAEDTATAILRKKRKPNSLVVDDATNDDNSVITLSSNTMETLQLFRGDTVVVKGKRRKDTVLIVLTDEEMEDGVARINRVVRNNLRVRLGDIVTINPCPDIKYAERISVLPLADTVEGLTGSLFDVYLKPYFVEAYRPIRKGDLFVVRGSMRQVEFKVVDVAPDEFGIVSQDTIIHWEGEPINREDEESSLAEVGYDDIGGCRRQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGMKARSNVVVMAATNRPNSIDPALRRFGRFDREVDVGIPDPTGRLEILRIHTKNMKLADDVDLEQIAAETHGYVGSDLASLCSEAAMQQIREKMDMIDLDEDEIDAEVLDSLGVTMDNFRFALGSSNPSALRETVVEVPNVRWEDIGGLEEVKRELRETVQMPVMYAEKFLRFGVTPSKGVLFFGPPGTGKTLLAKAIANECSANFISVKGPELLSMWFGESESNVRDIFDKARAAAPCVVFLDELDSIAKARGASAGDSGGGDRVVNQLLTEMDGVNSKKNVFVIGATNRPDQIDPALMRPGRLDQLIYVPLPDEEARFSILQTQLRHTPVAEDVDLRAVAKATHGFSGADLEFVVQRAVKLAIKDSIEEDIKRENETGEAPADDVVMDEDASVSQVQRHHVEEAMKMARRSVSDAEVRRYEAYAHQLLTSRGLTGFQFDSADSNTNGPSFGNDGADDLYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	NPPKDTYSAEDTATA CCCCCCCCHHHHHHH	27.55	21712547
32	Phosphorylation	DTYSAEDTATAILRK CCCCHHHHHHHHHHH	19.88	21712547
34	Phosphorylation	YSAEDTATAILRKKR CCHHHHHHHHHHHCC	19.14	24763107
302	Phosphorylation	MSKMAGESESNLRKA HHHHCCCCHHHHHHH	45.46	24763107
304	Phosphorylation	KMAGESESNLRKAFE HHCCCCHHHHHHHHH	50.90	21712547
478	Phosphorylation	NFRFALGSSNPSALR CCHHHCCCCCHHHHH	28.00	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC48_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC48_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC48_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUT1_SCHPO	cut1	genetic	15507118
SECU_SCHPO	cut2	genetic	15507118
SECU_SCHPO	cut2	genetic	16904908
CUT1_SCHPO	cut1	genetic	16904908
SREBP_SCHPO	sre1	genetic	22086920
SLX8_SCHPO	slx8	physical	24265825

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.