SREBP_SCHPO - dbPTM
SREBP_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SREBP_SCHPO
UniProt AC Q9UUD1
Protein Name Sterol regulatory element-binding protein 1
Gene Name sre1 {ECO:0000312|EMBL:CAB52036.1}
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 900
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Processed sterol regulatory element-binding protein 1: Nucleus . Accumulates at promoters of the target genes (PubMed:16537923).
Protein Description Transcriptional activator required for transcription of genes required for adaptation to anaerobic growth like those implicated in the nonrespiratory oxygen-consumptive biosynthetic pathways of sterol, heme, sphingolipid, and ubiquinone biosynthesis. May monitor oxygen levels through sterol synthesis steps which require oxygen..
Protein Sequence MQSSIPSVSVSVASPAMETPTKASPDSKSPNSVGAIPSSSPLASSTKASTSTPFVENCSNLLCDLASIVEDSPPTLTNTSLSPHSFSLSDMESSMSNWLNPFAFDNTMNSAPPLFTSTNMGSPNSLENSTNPLLSNCGSPNSFQNETFTGPSLNEFDADDKIQRQMKILHSVDTIDPSTVQNYPSADMSNPEVKLKTEEIITPMDTTCKPEPSAKKIKLSPSSEDSCSIPETLPFSAPKSRGSLSPSETPDFVAGPGGKPKKTAHNMIEKRYRTNLNDRICELRDAVPSLRAAAALRCGNSLDDEDLGGLTPARKLNKGTILAKATEYIRHLEAKNKELQKTNKQLSDRLAFYEDPSMAPPSNDTRAVNSVNVVSSSDYSVHQSSRPNLTQRAFTSPTLNTMGRTALNGMVGLGLFNYFGNDSSQSVYGLFALPPFLMSPFTGTVLFNMLKIGVVLLGLFYLLHDNSLFKGFKGEKKSKVSTRSSMSPSSILFRKTVFEKYCLLDHSTSTISLFFGLLIFTLKSAYGYLTHRLSALYTSSENWVYSEQQLAEVRNMEKLLDAQLMGGDAKVDRLRLLMVFASSFSLPPSSHTCALQAMYCQLIFSNTSVPSAIVSKCVAFFWNAAKKQHSKSSVHAELRELPECTANLIENSHADDVFSPNMVERLWVLAKCTRDSAQMSDSIISSLSDVLVLSPLEVLASWYAADLLDALLMESLSRKVEISEIEEIISLCPKNSSIIRHALLAKLVLFPENTADSLNEVLAAYKNTLDLCSQDKRKQSSVLKINLSKLFTLHSCLSLALQRLGYGDVSKRMYQEIFVPDSDADITPLSFIISWTALNTFAPICTSPKENDVVEKMAMYVRTAIGTLKIQDLKLSRKLINSCIDIGSRLQEDLGYVSSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
32PhosphorylationPDSKSPNSVGAIPSS
CCCCCCCCCCCCCCC		25.8829996109
38PhosphorylationNSVGAIPSSSPLASS
CCCCCCCCCCCCCCC		37.0229996109
39PhosphorylationSVGAIPSSSPLASST
CCCCCCCCCCCCCCC		30.5329996109
40PhosphorylationVGAIPSSSPLASSTK
CCCCCCCCCCCCCCC		28.4229996109
223PhosphorylationKIKLSPSSEDSCSIP
CCCCCCCCCCCCCCC		49.1325720772
228PhosphorylationPSSEDSCSIPETLPF
CCCCCCCCCCCCCCC		45.1725720772
240PhosphorylationLPFSAPKSRGSLSPS
CCCCCCCCCCCCCCC		40.5929996109
243PhosphorylationSAPKSRGSLSPSETP
CCCCCCCCCCCCCCC		25.2721712547
245PhosphorylationPKSRGSLSPSETPDF
CCCCCCCCCCCCCCC		28.2521712547
247PhosphorylationSRGSLSPSETPDFVA
CCCCCCCCCCCCCCC		51.2129996109
490PhosphorylationRSSMSPSSILFRKTV
CCCCCHHHHHHHHHH		27.0525720772
583PhosphorylationLLMVFASSFSLPPSS
HHHHHHHHCCCCCCC		18.5427738172
585PhosphorylationMVFASSFSLPPSSHT
HHHHHHCCCCCCCHH		41.7527738172
592PhosphorylationSLPPSSHTCALQAMY
CCCCCCHHHHHHHHH		11.0427738172
599PhosphorylationTCALQAMYCQLIFSN
HHHHHHHHHHHHHCC		4.6927738172
608PhosphorylationQLIFSNTSVPSAIVS
HHHHCCCCCCHHHHH		35.9627738172
898PhosphorylationQEDLGYVSSA-----
HHHHCCCCCC-----		16.4428889911
899PhosphorylationEDLGYVSSA------
HHHCCCCCC------		28.1428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligasehrd1O74757
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SREBP_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SREBP_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YGVA_SCHPOdef1genetic
21504829
E2AK2_SCHPOhri2genetic
21504829
YG58_SCHPOSPBC56F2.08cgenetic
21504829
G3P2_SCHPOgpd3genetic
21504829
KCC2_SCHPOcmk2genetic
21504829
SPC2_SCHPOspc2genetic
21504829
ZDS1_SCHPOzds1genetic
21504829
ATP5E_SCHPOatp15genetic
21504829
YIDH_SCHPOSPAC227.17cgenetic
21504829
NCPR_SCHPOccr1genetic
21504829
PROB_SCHPOSPAC17H9.13cgenetic
21504829
LYS1_SCHPOlys3genetic
21504829
HOSM_SCHPOlys4genetic
21504829
YI75_SCHPOSPAC977.05cgenetic
21504829
EST1_SCHPOest1genetic
21504829
BECN1_SCHPOatg6genetic
21504829
CUT8_SCHPOcut8genetic
21504829
EFTS_SCHPOtsf1genetic
21504829
LYS4_SCHPOlys2genetic
21504829
ARGJ_SCHPOSPBC1271.14genetic
21504829
YJD1_SCHPOSPCC594.01genetic
21504829
ARG56_SCHPOarg11genetic
21504829
OTC_SCHPOarg3genetic
21504829
AZET_SCHPOaca1genetic
21504829
YGRG_SCHPOSPBC365.16genetic
21504829
YE87_SCHPOSPAC9G1.07genetic
21504829
PVG3_SCHPOpvg3genetic
21504829
PNK1_SCHPOpnk1genetic
21504829
OFD1_SCHPOofd1physical
22017871
VTS1_SCHPOSPBC13E7.03cgenetic
22681890
PROB_SCHPOSPAC17H9.13cgenetic
22681890
LYS1_SCHPOlys3genetic
22681890
NCPR_SCHPOccr1genetic
22681890
NAGS_SCHPOarg6genetic
22681890
HOSM_SCHPOlys4genetic
22681890
YI75_SCHPOSPAC977.05cgenetic
22681890
HHP2_SCHPOhhp2genetic
24327658
TOM70_SCHPOtom70genetic
24327658
OFD1_SCHPOofd1genetic
24327658
SREBP_SCHPOsre1physical
26771498
PEP12_SCHPOpep12physical
26771498
YQ13_SCHPOemc4physical
26771498
SCAP_SCHPOscp1physical
25771684
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SREBP_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-898 AND SER-899, ANDMASS SPECTROMETRY.

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