| UniProt ID | BECN1_SCHPO | |
|---|---|---|
| UniProt AC | P87117 | |
| Protein Name | Vacuolar protein sorting-associated protein atg6 | |
| Gene Name | atg6 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 464 | |
| Subcellular Localization |
Endosome membrane Peripheral membrane protein. Vacuole membrane Peripheral membrane protein. Preautophagosomal structure membrane Peripheral membrane protein. Cytoplasm. |
|
| Protein Description | Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific vps34 PI3-kinase complex I. This complex is essential to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the preautophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II (By similarity). Plays a role in meiosis and sporulation.. | |
| Protein Sequence | MQYLCQRCHSLINFKDVYDDDLLKLKNLPKSRFVQASSLTEMNESGESDDQMNSSSEDYPAQRLQLYKKTISEGDYNFDNVPPPELRTPTLDSFVVLPAAKDGYEEEKNSPEEVNDLFSWKIEIYNRIFDLLSSKTKVDHPLCVECAELLTEEMSKTLRALKEEKKMYFNYDNFLSSQTVHEENTAALDSEIDELMKQINEKEEKIEEISDETDKLQKLLRELDEEKEKVYAEEQEFYNNLNQFQIKKLSLERQYDCANLEFEHNSRKLEKLQKMNVFSDIFYISHYSEPNGEGSIATINGLRLGRLPSQKVNWAEINAAWGMTVLLLDVLTEKLDFHSSSYQLKPFGSQSFIIRFDRDPNGNQVKPTKLDLFSSGELKIFMNRRFDQGMVAFLDYLHQFGDFCAAKTPSAVLPYAIENDRIGGKCIRLAFNQDENWTRALKFVLTDIKFLEAYVSSQDKQSNF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | EMNESGESDDQMNSS CCCCCCCCCCCCCCC | 25720772 | ||
| 88 | Phosphorylation | VPPPELRTPTLDSFV CCCHHHCCCCCCEEE | 25720772 | ||
| 90 | Phosphorylation | PPELRTPTLDSFVVL CHHHCCCCCCEEEEE | 25720772 | ||
| 93 | Phosphorylation | LRTPTLDSFVVLPAA HCCCCCCEEEEEECC | 25720772 | ||
| 110 | Phosphorylation | GYEEEKNSPEEVNDL CCHHCCCCHHHHHHH | 24763107 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BECN1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BECN1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BECN1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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