dbPTM

SEC2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SEC2_SCHPO
UniProt AC	O13930
Protein Name	Rab guanine nucleotide exchange factor sec2
Gene Name	sec2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	527
Subcellular Localization
Protein Description	Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity)..
Protein Sequence	MPDVSNVRVKPNQHPYEKEVNGKLMSQEEILSQKLVAAIERQAALDDKYATEVHRNEALSERIRELEAKLSAKKSFDEELVKFHNLEEKLQLTETKCRNAESEKSRVENELEDLTSSLFEEANRMVANARKETVASEKRVNQLKKQLVDAETLLSSTQHQLTELKDVMHSMSDSHEQNNALHPPLSRTTSFVADNVSVGSFASSTSGLDILTGTSARESLDAKEISSDKHLNISGERPATFPNPTFIEGSDERRSASSLGHRTNNNQNQLIRFSTQIRSSSTSPPRSPLIISDSPSSSIIHNPHPTHPSASAMNYMNPCFLEFHAFFNYPMKFARSRSAYSTSANYSNTPPRNTVTPSTARSSTLSQNPSSSSNSIPLISRNLRDFSFFKRCLEEDIEPTLRLDHASGLSWLTRRSVFTAILESSLIINPLHSTSLLSSQPCSLCGFNRTQPLRQFEFRSRPDSTSHASCTYCVARLRSVCNFVAFLHQICKGVWSSCSLEKAWDECLKKREAMFLSRVGLAKELEG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	AKLSAKKSFDEELVK HHHHCCCCCCHHHHH	36.90	28889911
186	Phosphorylation	NALHPPLSRTTSFVA CCCCCCCCCCCCEEE	33.10	29996109
255	Phosphorylation	EGSDERRSASSLGHR CCCCHHCCHHHHCCC	38.43	29996109
257	Phosphorylation	SDERRSASSLGHRTN CCHHCCHHHHCCCCC	27.60	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SEC2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SEC2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SEC2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEC2_SCHPO	sec2	physical	26771498
YAWC_SCHPO	SPAC3F10.12c	physical	26771498
YF75_SCHPO	spa2	physical	26771498
RYH1_SCHPO	ryh1	physical	26771498
TEA3_SCHPO	tea3	physical	26771498
MUG79_SCHPO	spo7	physical	26771498
ATG11_SCHPO	atg11	physical	26771498
MOC3_SCHPO	moc3	physical	26771498
CBH2_SCHPO	cbh2	physical	26771498
YH7G_SCHPO	SPBC16G5.16	physical	26771498
AP1M1_SCHPO	apm1	physical	26771498
YQ52_SCHPO	SPCC162.02c	physical	26771498
NU211_SCHPO	nup211	physical	26771498
COG4_SCHPO	cog4	physical	26771498
VATD_SCHPO	vma8	physical	26771498

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SEC2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, AND MASSSPECTROMETRY.	18257517 [Abstract]