dbPTM

VATD_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VATD_SCHPO
UniProt AC	O59823
Protein Name	V-type proton ATPase subunit D
Gene Name	vma8
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	285
Subcellular Localization
Protein Description	Subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system..
Protein Sequence	MASKQRENVFPTRMTLTTMKTRLKGAQTGHSLLKRKSEALKKRFREIVVNIEQAKQKMGRVMQIAAFSMAEVGFAMGNNINFEIQQSVKQPRLRVRSKQENISGVFLPTFEMNLDESIDDFQLTGLGKGGQQIQKARQVYEKAVETLVQLASYQSAFVLLGDVLQMTNRRVNSIEHIIIPRLENTIKYIESELEELEREDFTRLKKVQKTKENAEKADSVTKEEHQGGSNTLQQTKDVGGAIAPAAEVGKEVINEVENSKDDTYSLPSTSTDDEEENDSDEEVIF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
219	Phosphorylation	ENAEKADSVTKEEHQ HHHHHHCCCCHHHHC	36.22	28889911
229	Phosphorylation	KEEHQGGSNTLQQTK HHHHCCCCCCCCHHC	33.20	21712547
259	Phosphorylation	VINEVENSKDDTYSL HHHHHHHCCCCCCCC	24.77	21712547
270	Phosphorylation	TYSLPSTSTDDEEEN CCCCCCCCCCCCCCC	33.89	27738172
279	Phosphorylation	DDEEENDSDEEVIF- CCCCCCCCCCCCCC-	59.51	27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VATD_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VATD_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VATD_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VATD_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VATD_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219, AND MASSSPECTROMETRY.	18257517 [Abstract]