dbPTM

ISH1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ISH1_SCHPO
UniProt AC	Q9Y7X6
Protein Name	Stress response protein ish1
Gene Name	ish1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	684
Subcellular Localization	Nucleus membrane .
Protein Description	Has a role in maintaining cell viability during stationary phase induced by stress response. Activated by the spc1 MAPK pathway..
Protein Sequence	MRSRSVASLGVLLAIVFYIFTYGFSTYRKNDTSAVKTWLEEHSIPYGSRSSPSDFQQFISESYDSLVPNLDKWSGHNLNSWLGKKTESSYLDAISNKIRKTGRKLSGSVEDARDATQEAWESQKASLFESWSDSQLRAFLARHSPQFAAKEKKGILEKLSPASLRETAAKEYDALTSKLGNTGDWIYDTWSDNELRTWLHDVGVPISSHESTRSHLLRKLKNYISTKADEAQPSVEAVKGKASEKAKQAGEFVSDKAGDAKELVNEKSSEAGQYAGQKMEEGGELLQEISKRRGRFGNWWANSGLKAYFDAHGIPAYQPSPIDQFYAHLRRQYYLKTNGYQALKSKAYEEASNVADSASSIASNVASGATEAYQGAASGASRFTEGAKTAAESVTSAFEHNKDTATSKAKQMKGKAASLGSTASEKVGEAADYAAETASKVASKAASKVRETIDETIIERWQDSKLKEFLFLRGVPVPQRSTKDQLLDLVRKHFNKGAVPNWAAYFDTLSSKELSAWIKEYKKHYHGKLHPSKDREHLFQNACNIYRAIAEKADKSVLQSIQSKFPKATVPGYDSWSNEDLKSALKEYGDSIGKVFNRKDAIERLKRHDILFYGPVVADKAKSGVSGFLRRVASFMGFGTRDVAEIKLGENIQKVKDTASKASSAVSSAGDYVETNVKKAQRVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
481	Phosphorylation	GVPVPQRSTKDQLLD CCCCCCCCCHHHHHH	34.26	25720772
482	Phosphorylation	VPVPQRSTKDQLLDL CCCCCCCCHHHHHHH	40.61	25720772
667	Phosphorylation	SKASSAVSSAGDYVE HHHHHHHHHHHHHHH	17.75	25720772
668	Phosphorylation	KASSAVSSAGDYVET HHHHHHHHHHHHHHH	29.67	25720772
672	Phosphorylation	AVSSAGDYVETNVKK HHHHHHHHHHHHHHH	10.16	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ISH1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ISH1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ISH1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ISH1_SCHPO	ish1	physical	11751918
BIS1_SCHPO	bis1	physical	11751918
RS6B_SCHPO	rps602	physical	11751918

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ISH1_SCHPO

Related Literatures of Post-Translational Modification