dbPTM

VMS1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VMS1_SCHPO
UniProt AC	O74977
Protein Name	VMS1 homolog C1827.04
Gene Name	SPCC1827.04
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	600
Subcellular Localization	Cytoplasm . Mitochondrion. Endoplasmic reticulum membrane Peripheral membrane protein.
Protein Description	Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability (By similarity)..
Protein Sequence	MGDISKHNIFSLPEDILAKLELREEYSVEEKTDSANLSNQGDIVDSTQKNISSCVNCQIDNLHTLDERKSHIKSDWHRFNTKRKITKLPPVSQDEFESIIEDLPESLSGSESETNSESEEDNFQIEKAFKQSLNIGKVDSADENNNQRTNSPLTWFQLSNASAEVPTYIGVYKHMFSGNNHITKDLLVQQQNHNRQKPLQLAMFMVGGGHFAAMIASNEFNPRDPHVPKVLAQKTIHRYTTRRKQGGSQGAADNTKGNIHSAGSGLRRYNEQALIKDIQQVFKDWGKLLETCDLIFVRAIGSSNRSIFFSQPGALISPKDPKLRVFPFTTKRATHSELLRCYKELVTPKISHVDSISIKAQEEERKRQAEIEKEIRQSRLQEEERKKKKLAKYTEVIISNLKASNIEAFLEYLRSNDLSINFQFYPKNVHLHTSTPLHYAVTQKNAKLVAKLLRNGADPAMLNGNGKTPFEISTGNKEVKDEFLIARHELGESFFDWEAAKVGAPQSREQIQKQRQKAKTKLENQRRDKERQEELRRKEAMQKIEEQSKRDYDKLHGEGHSLGINNVRKVDELQSLSPEMRMRIEREKRAAAAMKRMQTK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	EYSVEEKTDSANLSN HCCCCCCCCCCCCCC	38.17	27738172
38	Phosphorylation	KTDSANLSNQGDIVD CCCCCCCCCCCCCCC	27.24	28889911
140	Phosphorylation	LNIGKVDSADENNNQ CCCCCCCCCCCCCCC	40.38	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VMS1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VMS1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VMS1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
YEG5_SCHPO	mga2	genetic	19547744

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VMS1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND MASSSPECTROMETRY.	18257517 [Abstract]