FKBPH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKBPH_SCHPO
• UniProt AC: Q10175
• Protein Name: Probable peptidyl-prolyl cis-trans isomerase C27F1.06c
• Gene Name: SPAC27F1.06c
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 362
• Protein Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)..
• Protein Sequence: MSKEETLYSVKVDQERVPLFDEDFYKGFRSELSVRFTMAALDPRAKSNDAVTVNVITRLEHPEEDGEESDEELFQEEKFTLCTLKKGSVYQQPIDIIFSPGEEVFFERVGGDIPVYLSGTCIITNIPEEEDSSDLENDFLYGADEFSSDEEEMDDISVTSSEEEEEENGARIEELNSDEEDAEQAEEEILEKPVPKDEVAEKHSKDKLKKEEKEKKTAVDVSDSVNGKKRKTEPAGEGEQTEKKSKSTKTYPKQVLEGNVTVQDKVKGDGPAAKRKKRVSMRYIGRLTNGKVFDKNITGKPFTFNLGLEEVIKGWDVGIVGMQVGGERTIHIPAAMAYGSKRLPGIPANSDLVFDVKLLAVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	DFYKGFRSELSVRFT HHHHCHHHHHHHEEE	40.40	25720772
47	Phosphorylation	ALDPRAKSNDAVTVN CCCCCCCCCCCEEEE	38.67	21712547
57	Phosphorylation	AVTVNVITRLEHPEE CEEEEEEEECCCCCC	25.56	21712547
69	Phosphorylation	PEEDGEESDEELFQE CCCCCCCCHHHHHHH	46.12	28889911
177	Phosphorylation	ARIEELNSDEEDAEQ CCHHHHCCCHHHHHH	60.05	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKBPH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKBPH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKBPH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
POM1_SCHPO	pom1	genetic	18818364
TAS3_SCHPO	tas3	genetic	18818364
PEF1_SCHPO	pef1	genetic	18818364
CID12_SCHPO	cid12	genetic	18818364
SDS23_SCHPO	sds23	genetic	22681890
PLB2_SCHPO	SPAC1A6.03c	genetic	22681890
CYB51_SCHPO	SPBC29A10.16c	genetic	22681890
MUG73_SCHPO	mug73	genetic	22681890

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-69 AND SER-177, AND MASSSPECTROMETRY.
PubMed: 18257517