dbPTM

PP2C3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PP2C3_SCHPO
UniProt AC	Q09173
Protein Name	Protein phosphatase 2C homolog 3
Gene Name	ptc3
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	414
Subcellular Localization
Protein Description	Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase..
Protein Sequence	MGQTLSEPVTEKHSVNGSNEFVLYGLSSMQGWRISMEDAHSAILSMECSAVKDPVDFFAVYDGHGGDKVAKWCGSNLPQILEKNPDFQKGDFVNALKSSFLNADKAILDDDQFHTDPSGCTATVVLRVGNKLYCANAGDSRTVLGSKGIAKPLSADHKPSNEAEKARICAAGGFVDFGRVNGNLALSRAIGDFEFKNSNLEPEKQIVTALPDVVVHEITDDDEFVVLACDGIWDCKTSQQVIEFVRRGIVAGTSLEKIAENLMDNCIASDTETTGLGCDNMTVCIVALLQENDKSAWYKKIADRVAANDGPCAPPEYAENHGPGWRSGDNNKKVIVPPNFHQVKLNGSDGYDKDANENSKEDDSTNGSLAAGFRWKEHFFPHKAEEENSSSETDIVNSNKDVADDHKEAVSAAD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
389	Phosphorylation	HKAEEENSSSETDIV CCCCCCCCCCCCCCC	38.22	24763107
390	Phosphorylation	KAEEENSSSETDIVN CCCCCCCCCCCCCCC	43.72	21712547
391	Phosphorylation	AEEENSSSETDIVNS CCCCCCCCCCCCCCC	44.32	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PP2C3_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PP2C3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PP2C3_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WIS1_SCHPO	wis1	genetic	7859738
ATP11_SCHPO	atp11	genetic	18818364
ASE1_SCHPO	ase1	genetic	18818364
ELOC_SCHPO	SPBC1861.07	genetic	18818364
SERB_SCHPO	ser2	genetic	18818364
SKI2_SCHPO	SPCC550.03c	genetic	18818364
ARP6_SCHPO	arp6	genetic	18818364
SWC5_SCHPO	swc5	genetic	18818364
VPH2_SCHPO	vph2	genetic	18818364
RAF2_SCHPO	raf2	genetic	18818364
REB1_SCHPO	reb1	genetic	22681890
YEG5_SCHPO	mga2	genetic	22681890
PYP1_SCHPO	pyp1	genetic	22681890
YNVD_SCHPO	far10	genetic	22681890
SUT1_SCHPO	sut1	genetic	22681890
PDK_SCHPO	pkp1	genetic	22681890
GCN5_SCHPO	gcn5	genetic	22681890
MU113_SCHPO	mug113	genetic	22681890
ERG5_SCHPO	erg5	genetic	22681890
ARP42_SCHPO	arp42	genetic	22681890
RL43B_SCHPO	rpl4302	genetic	22681890
PMP1_SCHPO	pmp1	genetic	22681890
LIZ1_SCHPO	liz1	genetic	22681890
HUS1_SCHPO	hus1	genetic	22681890
VPS3_SCHPO	vps3	genetic	22681890
SET1_SCHPO	set1	genetic	22681890
IQW1_SCHPO	iqw1	genetic	22681890
YBPD_SCHPO	SPBC16H5.13	genetic	22681890
FFT3_SCHPO	fft3	genetic	22681890
YHEI_SCHPO	SPBPB2B2.18	genetic	22681890
TBA2_SCHPO	atb2	genetic	22681890
MID1_SCHPO	mid1	genetic	22681890
YG41_SCHPO	cxr1	genetic	22681890
YQMA_SCHPO	SPCP1E11.10	genetic	22681890
EMC1_SCHPO	emc1	genetic	22681890
ASE1_SCHPO	ase1	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PP2C3_SCHPO

Related Literatures of Post-Translational Modification