dbPTM

PDK_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PDK_SCHPO
UniProt AC	Q9P6P9
Protein Name	[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
Gene Name	pkp1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	425
Subcellular Localization	Mitochondrion matrix .
Protein Description	Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism..
Protein Sequence	MSVLGKTLQEKVNLLAQYPQTGLSLKQLVYFGKNPTPGTLFRAGLFLRDELPIRLARRIQDLQNLSPMLRSMKRISSVKAAYGRSMEEIIELKGVELPKCLPKHARYHNAPKWRSSLMDSEILHNPSLANTHLDSSKGRYFETDFSDQDNGVDCNWPESLLKFNSNFAYLLNTIRTRHDNVAVEIALDIQEYRRKTNQIDNSIQIFLDRFYMSRIGIRMLLGQYIALVSEPPRENYVGVISTRANIYQIIEGAAENAKYICRLAYGLFEAPEIQIICDPSLEMMYVESHLNHAVFEILKNSLRATVEFHGVDSDFFPPIKVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTTASPTLTDDPHDIVSANSTTPMAGFGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLNRLCESAEPLQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
178	Phosphorylation	LNTIRTRHDNVAVEI HHHHHHCCCCCCEEE	30.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PDK_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PDK_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PDK_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YG58_SCHPO	SPBC56F2.08c	genetic	22681890
PPK14_SCHPO	ppk14	genetic	22681890
YAC5_SCHPO	cph1	genetic	22681890
ULP2_SCHPO	ulp2	genetic	22681890
YE08_SCHPO	SPAC17H9.08	genetic	22681890
ARP42_SCHPO	arp42	genetic	22681890
YOOH_SCHPO	SPBC887.17	genetic	22681890
PP2C3_SCHPO	ptc3	genetic	22681890
RM01_SCHPO	SPAC1610.02c	genetic	22681890
PRZ1_SCHPO	prz1	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PDK_SCHPO

Related Literatures of Post-Translational Modification