dbPTM

PUT2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PUT2_SCHPO
UniProt AC	O74766
Protein Name	Probable delta-1-pyrroline-5-carboxylate dehydrogenase
Gene Name	SPBC24C6.04
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	548
Subcellular Localization
Protein Description
Protein Sequence	MSQFAEFKLPAIKNEPPKHYGPNSADREGIVKAYKELEAELPVTIPVIIDGKEVETNTIGEQRCPFEHKKVVARYHRAGAKHVEDAIEAALRGKKVWESLPFADRSAIFLKAAHLISTKYRYKLMAATMIGQGKNIWQAEIDAGMEIIDFLRFNTKYASELYASQPPENTPGVWNRMEYRPLEGFVYAITPFNFTAIAGNLAAAPLLMGNVVLMKPSDHAVLSSYIVYQIFREAGLPAGALQFIPGDAVEVSKVCFNHPEFAGLHFTGSTAVFRSLWGTIGENVANGKYRTYPKIVGETGGKNFHLVHSSAEIKSAVVNAVRAAFEYQGQKCSALSRLYVSKYAWENGFRDELTKQVKSLKVGAPLTDFANFVGPVIHQASFNKLKKVLESAASDSEIEVLAGGKADDSEGFFVEPTVLLSKNPKHDIFVNELFGPVLSVYVYEDDNLDAVCDLIDTTTPYGLTGSIFAQDRVVVRKLTDRLRNAAGNFYINDKCTGAVVGEQPFGGARASGTNDKAGSGMILSRFVSPRSIKDTFAYADSVLYPSNF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSQFAEFKL ------CCCCCCCCC	33.72	21712547
24	Phosphorylation	PKHYGPNSADREGIV CCCCCCCCCCCCCHH	34.38	21712547
56	Phosphorylation	IDGKEVETNTIGEQR ECCEEEECCCCCCCC	42.72	29996109
58	Phosphorylation	GKEVETNTIGEQRCP CEEEECCCCCCCCCC	37.47	29996109
106	Phosphorylation	SLPFADRSAIFLKAA HCCCCCHHHHHHHHH	26.68	25720772
309	Phosphorylation	KNFHLVHSSAEIKSA CCEEEEECHHHHHHH	24.62	21712547
310	Phosphorylation	NFHLVHSSAEIKSAV CEEEEECHHHHHHHH	18.29	25720772
315	Phosphorylation	HSSAEIKSAVVNAVR ECHHHHHHHHHHHHH	31.77	25720772
381	Phosphorylation	GPVIHQASFNKLKKV HHHHHHHHHHHHHHH	23.84	25720772
391	Phosphorylation	KLKKVLESAASDSEI HHHHHHHHHCCCCCE	25.60	28889911
394	Phosphorylation	KVLESAASDSEIEVL HHHHHHCCCCCEEEE	41.19	28889911
396	Phosphorylation	LESAASDSEIEVLAG HHHHCCCCCEEEEEC	37.67	28889911
409	Phosphorylation	AGGKADDSEGFFVEP ECCCCCCCCCEEECC	39.92	25720772
417	Phosphorylation	EGFFVEPTVLLSKNP CCEEECCEEEEECCC	15.41	27738172
531	Phosphorylation	SRFVSPRSIKDTFAY EECCCCCCCCCHHHC	37.06	25720772
535	Phosphorylation	SPRSIKDTFAYADSV CCCCCCCHHHCCCCC	12.74	25720772
541	Phosphorylation	DTFAYADSVLYPSNF CHHHCCCCCCCCCCC	13.07	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PUT2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PUT2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PUT2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PUT2_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PUT2_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391; SER-394 ANDSER-396, AND MASS SPECTROMETRY.	18257517 [Abstract]