| UniProt ID | CLR6_SCHPO | |
|---|---|---|
| UniProt AC | O59702 | |
| Protein Name | Histone deacetylase clr6 | |
| Gene Name | clr6 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 405 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation.. | |
| Protein Sequence | MGFGKKKVSYFYDEDVGNYHYGPQHPMKPHRVRMVHNLVVNYNLYEKLNVITPVRATRNDMTRCHTDEYIEFLWRVTPDTMEKFQPHQLKFNVGDDCPVFDGLYEFCSISAGGSIGAAQELNSGNAEIAINWAGGLHHAKKREASGFCYVNDIALAALELLKYHQRVLYIDIDVHHGDGVEEFFYTTDRVMTCSFHKFGEYFPGTGHIKDTGIGTGKNYAVNVPLRDGIDDESYESVFKPVISHIMQWFRPEAVILQCGTDSLAGDRLGCFNLSMKGHSMCVDFVKSFNLPMICVGGGGYTVRNVARVWTYETGLLAGEELDENLPYNDYLQYYGPDYKLNVLSNNMENHNTRQYLDSITSEIIENLRNLSFAPSVQMHKTPGDFTFENAEKQNIAKEEIMDERV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of CLR6_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CLR6_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CLR6_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CLR6_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CLR3_SCHPO | clr3 | genetic | 15632061 | |
| PST2_SCHPO | pst2 | physical | 12773392 | |
| EAF3_SCHPO | alp13 | physical | 12773392 | |
| PRW1_SCHPO | prw1 | physical | 12773392 | |
| PST1_SCHPO | pst1 | physical | 12526748 | |
| CLR3_SCHPO | clr3 | genetic | 9755190 | |
| CLR1_SCHPO | clr1 | genetic | 9755190 | |
| JHD1_SCHPO | epe1 | genetic | 18818364 | |
| JHD1_SCHPO | epe1 | genetic | 12773576 | |
| RLF2_SCHPO | pcf1 | genetic | 24478943 | |
| CDS1_SCHPO | cds1 | genetic | 24478943 | |
| YJNJ_SCHPO | nts1 | physical | 25002536 | |
| MU165_SCHPO | mug165 | physical | 25002536 | |
| YDRC_SCHPO | png3 | physical | 25002536 | |
| FKH2_SCHPO | fkh2 | physical | 25002536 | |
| ING2_SCHPO | png2 | physical | 25002536 | |
| EAF3_SCHPO | alp13 | physical | 25002536 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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