dbPTM

CTU2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CTU2_SCHPO
UniProt AC	Q9UUC7
Protein Name	Cytoplasmic tRNA 2-thiolation protein 2 {ECO:0000255\|HAMAP-Rule:MF_03054}
Gene Name	ctu2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	366
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with ctu1 that ligates sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation..
Protein Sequence	MQNTALDNSADSKCSKCDNKATVLTKSDAVCDSCFVRRIENKIRRQFELVRPNLQGRKSKRAMLAISGGISSMAMLETANYLSKYRDDNYRPMFDELLAVHFQWGTDSAVAKTIEESISKNYPKCPFKVIGEAELLNRTIATDSRGNIEINADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGDSGTTIAARVLELVAEGRGFAIPWYTSVCSKLPNCDTFLLRPLREVLSSDLKSYMNIKGLAFCDSLIEARPNTIHGVTESYFSSLNDTFPSLVSTVVKMSSKLHVPSTEAICTICNLPMQEDAETWLQKTTVEHPDSVEGIKNQNVCYGCSVSLKSLKGTLHIPDIEKEGI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of CTU2_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CTU2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CTU2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CTU2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CTU2_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CTU2_SCHPO

Related Literatures of Post-Translational Modification