SEC74_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEC74_SCHPO
• UniProt AC: Q10491
• Protein Name: Arf guanine nucleotide exchange factor sec74
• Gene Name: sec74
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 928
• Subcellular Localization: Cytoplasm . Cell septum . Cell tip .
• Protein Description: Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Involved in vesicular transport (By similarity)..
• Protein Sequence: MDESSRIASSSALHGLDEMVSAHKPSPPLPSRRKGKSALRSALEKKNRKSKSKPKVTITSDTPKVSSQHSPVSSAYTGDSTTDLDSKSGHSSSQKLSNKVSSALKLTIPKRWRSSKSSSSQCSSPFLPTSSSNGHGDDASLNLPDKKSRPSSQSSIFLSNWSTIFSSNASPTDSQLSPTHTSTIAELAASTLSIFPSGSYAGSTFGSPSRSSIDSSTYLPRSKSVNSLSSNFSARTPASNQSSVSEDFGAAPNCDHKHNSVTLSDFALPDIDQHDTVETILEKVEFTIPKQFTPAILSQGTSSLLKLCLRKYLSVVNFKCISLDMALRKFLAVYVLPNETQQIDRVLSTFSDQYFHCNPDLYDSSDECYILTFSLMILHTDFFNIHNRQKMTRAEFISNTNLPTILPEILECFYDNITYTPFVHVEHIGCVVTSPSNEKPSLSQRLGDSQFRLTKRNTFATESDHQALQEQLTGFRINLDSILDLKKIDSVRTSIESPTRTADDLYKEFARAPFLQIVSHRSQPQAFSYHFEPSAESESTNPAIINVKVFKLGILIQNEKVRKDRLLSNREVGVILTSSQLMFFKNVYWISGLLDQLEDFKRSHSFSPCYFSPHLTSLSADYIIPLSDLVAYGDGSRIENELYSFSVKQKNQRTHVFSVTNVDELNDWLVKINFVSTFATAGLAPRERLPCVESSDKSIKASVSVLPDIYEDSDAMSKASKETRSEVLECSKVRVYIVQNRIYKLEEALRQGESKMTVQRRNAANILHLEPIQSRTRIRLARCSNTLKKNMLAQMIEIQKFKISIKFLKEDLEMDSHLQDYLRSVFPSSVMGKENASEDTILESNFRNHSNPSVRRSNLRVGKTVESVQNTKLKSVENDSGKAETETVGKNPEVVRKSPAKLPNIANIMTVNGHRYSVVELPDDFLRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	TSDTPKVSSQHSPVS CCCCCCCCCCCCCCC		24763107
67	Phosphorylation	SDTPKVSSQHSPVSS CCCCCCCCCCCCCCC		28889911
70	Phosphorylation	PKVSSQHSPVSSAYT CCCCCCCCCCCCCCC		29996109
73	Phosphorylation	SSQHSPVSSAYTGDS CCCCCCCCCCCCCCC		29996109
132	Phosphorylation	PFLPTSSSNGHGDDA CCCCCCCCCCCCCCC		27738172
211	Phosphorylation	TFGSPSRSSIDSSTY CCCCCCCCCCCCCCC		25720772
212	Phosphorylation	FGSPSRSSIDSSTYL CCCCCCCCCCCCCCC		25720772
215	Phosphorylation	PSRSSIDSSTYLPRS CCCCCCCCCCCCCCC		25720772
216	Phosphorylation	SRSSIDSSTYLPRSK CCCCCCCCCCCCCCC		25720772
227	Phosphorylation	PRSKSVNSLSSNFSA CCCCCCCCCCCCCCC		28889911
262	Phosphorylation	DHKHNSVTLSDFALP CCCCCCEEHHHCCCC		21712547
837	Phosphorylation	VMGKENASEDTILES HCCCCCCCCCCHHHH		25720772
840	Phosphorylation	KENASEDTILESNFR CCCCCCCCHHHHHCC		25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEC74_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEC74_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEC74_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENO11_SCHPO	eno101	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.