dbPTM

MNL1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MNL1_SCHPO
UniProt AC	O94726
Protein Name	ER degradation-enhancing alpha-mannosidase-like protein 1
Gene Name	mnl1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	787
Subcellular Localization	Endoplasmic reticulum lumen.
Protein Description	Alpha-mannosidase-like protein involved in endoplasmic reticulum-associated degradation (ERAD). Delivers misfolded glycoproteins to proteasomes. It lacks mannosidase activity..
Protein Sequence	MGSLHSIFCVCLILLCIFKENSIVGAINSARMVELRETSRRLFYHGYNNYMQFAFPNDELAPLSCEGLGPDYENPNNIGVNDVRGDYLLTLVDVLDTLVVLGDREGFQDAVDKVIHHINFERDTKVQVFEATIRILGGLLSSHIFASEEKYGFQIPLYKGELLTLATELAERLLPAFRTPTGIPFARINLMKGVAYREVTENCAAAASSLVLEFSMLTALTGNNKFKASAENAFFSVWKRRSGIGLLGNSIDVLSGRWIYPVSGVGAGIDSFYEYAFKSYIFLGDPRYLEVWQKSLESLRHYTASLNEYYYQNVYSANGMVMSRWVDSLSAYFPGLLVLAGELELAKKMHLYYFSIYLKFGQLPERYNLYTKSIELNGYPLRPEFAESTYYLYRATKDVFYLHVGELLLSNIENHLWTPCGFAAVENLEKYTLSNRMESFFLSETLKYLFLLFDDDNPIHRSHHDFIFTTEGHLFPVTNQTRLSTSQRIYDGGEVCVAEDYDRSKWPMLYSLIASRDDYDYVSHLVGIDNKAIPSYLIDPSGVCKRPEYSDGFELLYGSALVSPIKSVERVTNNVYISDIIGNKLKFVQKEGSNSLFLYTAGAESINENDTVFLTDPDYETFTRPDALYFDRTIAQLENPNSGQKTFGKFLQFDNDNSLPSKVFKTVLLNNSMCQKPSDTLDKDTAYIAPLGNCSWVQQAKNTNKAGLLILITDGEFINPLENIHSQNSLFNWVKPYIPPTILLKNENNFVSKWANVSVRQSDFDAPSYFQGTPVSNLYLCLKCINS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
479	N-linked_Glycosylation	GHLFPVTNQTRLSTS CCEEECCCCCCCCCC	41.27	-
609	N-linked_Glycosylation	GAESINENDTVFLTD CCCCCCCCCCEEECC	45.85	-
670	N-linked_Glycosylation	VFKTVLLNNSMCQKP HHHHHHCCCCCCCCC	34.08	-
693	N-linked_Glycosylation	AYIAPLGNCSWVQQA EEEEECCCCHHHHHC	25.08	-
756	N-linked_Glycosylation	NFVSKWANVSVRQSD CCCCCCCCEEECCCC	26.02	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MNL1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MNL1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MNL1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MNL1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MNL1_SCHPO

Related Literatures of Post-Translational Modification