NOT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NOT1_SCHPO
• UniProt AC: P87112
• Protein Name: General negative regulator of transcription subunit 1
• Gene Name: not1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 2100
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity)..
• Protein Sequence: MKSQEQQTPETREKSSSTSESGHPISLDSKTPPPNDSKIESIVKAQILFLLSTLREDQYDTKLEQIRQLINKNAPRVYHHFLRRLIQGNSYRIFGTGKSSDGLATYKLLLDELKSLTKSWVMAKRFSDAISGSDSEVFEDFDIEAFLDHFQFSPLERTNLLIGLTTSVKPTLAKKASALLKNTFQSLLNQLSDPTQQQSIDKNDLDLLREGLFTTDYDRIPLIKVPKFDAIIEKKLANSRPLTALFGPMKASKATLKSMKEAILKKYPPGTATETDVAYLINSLVAIHDYGAWDTVLMGKAIVSSFENLNWEAMLSMFDNPKFMITGTPSLVLFFTIFTNAYKLRQTNFTLDFLWVLWRNPLPQLSIISHIILSPTSMFDIREFNVNPVVSVDSLKDYSEELVNYAKIYEKSNLNCIELVQILLRLLSEVVTYETSLFLNFLDEKVSAELLLLGTLQLPLAWNPVQESLAFQWCSDFFSNFKEHKFVFVRIERTNPQFLFAFLRSLWLKDSSSVNQVVEFIIENDFTSHIGNIQPNRFALEIAALAAARKALSFQDWLDKKMLEFEDADGLNVFLVEVLDFLMSRAALQKNESEQKEESVVLSIDTVNVLLTTLMDNVSISEEVSEHIKDVQILCLQVYPRLFSLGHDRDSIVIATNTTNSFSPDVESEVESYFQALYERRISIGKIVLTLQNFKKSENPRDLDLFACLQHSLFDEYRFFPDYPLEALALTAVLFGSLIQFELLSFVPLGVALRYVYQALLMPTDSKMFRFGMQALVQFQEKLPKYINYCNLILGIPSLQLVRPDIYDSIREMIASNENTEVEKDKLDSFSALANPASPKAPEYTFVSIHVPPLNVPNAEGEIEESVCDNILFAINNLSQLNFNEKLKDVKDNLTPAYLPWFSHYIVTQRVSREANFLSLYGKFLEELKSSDLYKIVFRDTLQAILDIMNNNAETLSPSEKTNLKNLGSWLGSITLLRNKPITTLQVSFKDLLLEGIDSGRIDRVLPFVCKVLEKASSSVIFKPPNPWLMGILKLLVELYQFADFRLNLKFEIELLLNNLNVKMDNIEPSEMYRNHLVQKADLEKELPEDVLNAEFPDGTDVITQYIVAASSQITVTDAVAQVFGKPKPAIKNITQLIIQQSVLEIISAVVRRSVGIAAITTKSLLQKDFAAESNPSRLLLAARQMAKTLAGNLAMVTCREPLQMLMINNFRTIALQDVENVHAAVAQAIDELVSQNLFVASSVIESVASETAIAEIDAEIEHMIVERVRHRKTTPNLPFVDPAGAANLHLNLPSVLKLSSELTPQQFQLYENFDRLSLSTIMSNNSFTSLNGLRTDSADSTDALNSNLNNTVENEANQTALNYARNLLIIIGQLFQLAAQMPYTSMQEVPADHELHELVNQFLTGVASINHPIADHVFLLCAQECCRILLTDSKSPFILEVFSAILEYICQASTKTAINVSLYWNFSNDLEKLNLPIILSLIRFGILTSGEVDYHVARGVRSEQGSGPVTDFAIELLRTAVGGENPMALPGNFVNSITSLYEISESFSGETKQAYEQLVETMNKSVSPASEILSDLDNKQQLNDQIIIVFVSWVHLLRNSATNDETKAAFVYQLHKQGILSEPELCIQFFRCNLEAVLVAFLEAASVNAPDYFNVDAYASLLVNVVKYTEGSTEGTVSSKSVLFRKIIALIIGVFAELHNSMAEFVHQKTFFRLFSSILSELDDAKDVLESCFVDIYSVILECFLAIQPRSFPAFTFAWLSLISHSYLLPKVLLVNNDKINDLFSEILMSFLKFLDLKDDIDKAQFKLLYNGFLRIILVLLHDFPGFLATHCYQLIPYIPLECVQLRNMVLSAFPSDLHLPDPFAQGLKVGRLPEVTRAPLISNSVSASLEKFASALDLEACFSSSKPAEVAKLLLEVYSSQDTPTKLNEWANYFMLCLIRHATRDSPAKQAPQFQSKSPECVIISTMNRSCDSKCRYFLLTAIANQLRYPSSHTYYASCCFLYLFKSSSNNPQELLIKEQMTTVLLERIICNRPHPWGLLITFTELLKNEDYNFWKHPYIKRNDEICRLFDSLHEHVMAPSSANNVSTEEATELMGQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MKSQEQQTPETREKS CCCCCCCCHHHHHHC	23.84	24763107
15	Phosphorylation	TPETREKSSSTSESG CHHHHHHCCCCCCCC	25.43	29996109
17	Phosphorylation	ETREKSSSTSESGHP HHHHHCCCCCCCCCC	42.94	29996109
18	Phosphorylation	TREKSSSTSESGHPI HHHHCCCCCCCCCCC	38.16	21712547
19	Phosphorylation	REKSSSTSESGHPIS HHHCCCCCCCCCCCC	31.54	29996109
21	Phosphorylation	KSSSTSESGHPISLD HCCCCCCCCCCCCCC	42.01	24763107
29	Phosphorylation	GHPISLDSKTPPPND CCCCCCCCCCCCCCC	43.66	29996109
31	Phosphorylation	PISLDSKTPPPNDSK CCCCCCCCCCCCCHH	45.00	28889911
829	Phosphorylation	VEKDKLDSFSALANP HCHHHHHHHHHHCCC	31.38	21712547
838	Phosphorylation	SALANPASPKAPEYT HHHCCCCCCCCCCCE	28.34	28889911
1274	Phosphorylation	ERVRHRKTTPNLPFV HHHHCCCCCCCCCCC	47.65	29996109
1275	Phosphorylation	RVRHRKTTPNLPFVD HHHCCCCCCCCCCCC	17.14	29996109
1324	Phosphorylation	LSLSTIMSNNSFTSL CCHHHHHCCCCCCCC	29.07	29996109
1327	Phosphorylation	STIMSNNSFTSLNGL HHHHCCCCCCCCCCC	33.87	29996109
1329	Phosphorylation	IMSNNSFTSLNGLRT HHCCCCCCCCCCCCC	31.93	29996109
1330	Phosphorylation	MSNNSFTSLNGLRTD HCCCCCCCCCCCCCC	20.16	29996109
1341	Phosphorylation	LRTDSADSTDALNSN CCCCCCCCHHHHHHH	28.09	28889911
1342	Phosphorylation	RTDSADSTDALNSNL CCCCCCCHHHHHHHC	26.32	27738172
1503	Phosphorylation	HVARGVRSEQGSGPV HHHCCCCCCCCCCCH	31.68	25720772
1507	Phosphorylation	GVRSEQGSGPVTDFA CCCCCCCCCCHHHHH	39.35	25720772
1566	Phosphorylation	LVETMNKSVSPASEI HHHHHHHCCCHHHHH	23.87	21712547
1568	Phosphorylation	ETMNKSVSPASEILS HHHHHCCCHHHHHHH	23.11	28889911
1571	Phosphorylation	NKSVSPASEILSDLD HHCCCHHHHHHHCCC	28.67	25720772
1575	Phosphorylation	SPASEILSDLDNKQQ CHHHHHHHCCCCHHH	41.61	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NOT1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NOT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NOT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAF1_SCHPO	caf1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1341 AND SER-1568, ANDMASS SPECTROMETRY.
PubMed: 18257517