SYJ2_SCHPO - dbPTM
SYJ2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYJ2_SCHPO
UniProt AC Q9USQ6
Protein Name Inositol-1,4,5-trisphosphate 5-phosphatase 2
Gene Name syj2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 889
Subcellular Localization Cytoplasm .
Protein Description Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. Involved in distinct membrane trafficking and signal transduction pathways. Highly active against a range of soluble and lipid inositol phosphates. Active in dephosphorylating the 5-position of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 and to a lesser extent Ins(1,4,5,6)P4 (By similarity)..
Protein Sequence MQCYLKRKERSVAFITEKYAAIIQKPSVKDSDCIITFTCISLEEFEKIKEYELLFGGEKILGTLGLFNYVCEDMKEGVFLCVARKAKLVLRIGNRDPISKLENVSFISLDQELWDEELFEPMPRNSSPSSTFSTSTSDLNNIEKDNLVNSEYSSKYSSTTRIYPYHSLSQLTDLLTDGSFYVSTNISCFSRFQSEQPYGPKDIYCWNRFLITELDNHFSEAHILEKFPNLLLHCFRGYVERMFIDSMSMSIISKVSSYGSRQTYPPSGIDDSSYCSMFVETEFIVEIAQTVFSFVQVRGTVPCFWEEQFSSWYGPSISFLRSSQASQSLFNFHFSKLYKAYGDIYVIDLLQTKGFEASLYEAYKHHLMLLPFPAVVKKFHFTPDPARPDIDPRLETDLADDLKEMGYTQKSIENDMLESFQKGVFRINDLDCLGRTNVIQYQISRLVLKDIFFNLQIGVTFNILEYLRHLWSNNGDAIAKLITGVGSIGSSATRRGRKSIAGSLSDISKSFGRMYVGRYPDVESQNAILLLLGCFPNQSPVLISESVSSYIQGVLRQRRSEYRVERDFSIFSSTFNANGKVPSTDEFKRLLLPFGERTSAYDLYVVAVQEIITLNMSHLVSSSNQKLRIWEEKILMILNSRDSNNKYMLISSIQMAGVFLGVFIRKDDHLVVSKVTKTTRKTGFGGFSANKGAVAIEMNVCDSDFCFVSSHFAPKVNNISERNMEYTSISDNLVFPSGMKIYDHTNILWMGDFNYRIDSDNEEVRKLVELDDLDKLASYDQLCTEMKKGTVFHGLVEPQLTFLPTYKFDNGTNDYDTSDKQRVPSWTDRILATKSFTRNCYKSCDIRCSDHRPVFATFSLKIFSTCMDKKAGIIRDARIAYIKSKNSNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
135PhosphorylationPSSTFSTSTSDLNNI
CCCCCCCCHHHCCCC		25.3929996109
136PhosphorylationSSTFSTSTSDLNNIE
CCCCCCCHHHCCCCC		26.7525720772
137PhosphorylationSTFSTSTSDLNNIEK
CCCCCCHHHCCCCCC		39.6125720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYJ2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYJ2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYJ2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBLH2_SCHPOuch2genetic
22681890
YQJ9_SCHPOSPCC1840.09genetic
22681890
AP3M_SCHPOapm3genetic
22681890
MU178_SCHPOmug178genetic
22681890
TRX2_SCHPOtrx2genetic
22681890
RIA1_SCHPOria1genetic
22681890
FSC1_SCHPOfsc1genetic
22681890
YEX1_SCHPOSPAC1A6.01cgenetic
22681890
YEEB_SCHPOSPAC19A8.11cgenetic
22681890
AATM_SCHPOSPBC725.01genetic
22681890
GMA12_SCHPOgma12genetic
22681890
TOM70_SCHPOtom70genetic
22681890
EMC1_SCHPOemc1genetic
22681890
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYJ2_SCHPO

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Related Literatures of Post-Translational Modification

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