dbPTM

RIA1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIA1_SCHPO
UniProt AC	O74945
Protein Name	Ribosome assembly protein 1
Gene Name	ria1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1000
Subcellular Localization	Cytoplasm .
Protein Description	GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with sdo1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2 (By similarity)..
Protein Sequence	MPVIPPEKLVSLQKNQENIRNFTLLAHVDHGKTTLADSLLASNGIISSKLAGTVRFLDFREDEITRGITMKSSAISLFFKVISQNDEKRVEKDYLINLIDSPGHVDFSSEVSSASRLCDGAFVLVDAVEGVCSQTITVLRQAWIDRIKVILVINKMDRLITELKLSPIEAHYHLLRLVEQVNAVIGTFYTGELMQLADNDEVISDEGIYFAPEQGNVVFASAYDGWAFCLDQFSEFYEKKLGLKQKALTKCLWGDYYLDPKTKRVLQPKHLQGRRLKPMFVQFVLENLWAVYESAVSNRNLENIEKIIKALNIKVLPRDIKSKDPRNLLLAIFQQWLPLSTAILLTAIREIPSPINAQANRARKVLSSTPHYEMIDPDITLAMESCDASKEQPVLVYISKMVAFSERDLPNHRRKQLSAEEMKLIRSKLSESIESGINTISIEENVSSTNSDNLEGSTTDMDDDKDILIGFARIYSGTISVGQEVYVYGPKYDPVNPEKHITKVTVESLYLMMGQELVYLETVPAGNVFAIGGLAGTVLRTATLCSSPNGPNLVGVTQQMEPIVRVALEPVRPFEMNKLVTGLDMLNQADPCVQIAVEENGEHVIMCAGEIHLERCLKDLRERFAKIEIQASQPLVPYRETTIATPDLLAKNKELSIGFVTATLPVGGVTIGITVTPLSGSVVDFLLKHSKTIENVSSNFSKKNRNVVVSESLTKSMEEVLTPEKFYERLSKLLEEENSDLGELKNHLDSIIAFGPKRVGPNILFDKTKKMRDFRRQSDETKLIPSDLSEYVVTAFQLITHQGPLCAEPVQGICVSIDQFDISDDSEDSKLLTINNPQIPGQVISVVKESIRHGFLGWSPRLMLAMYSCDVQATSEVLGRVYGVVSKRRGRVIDEEMKEGTPFFIVKALIPVVESFGFAVEILKRTSGAAYPQLIFHGFEMLDENPFWVPTTEEELEDLGELADRENIAKRYMLNVRKRKGLLVEQKIVEKAEKQRTLKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of RIA1_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIA1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIA1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIA1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RIA1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIA1_SCHPO

Related Literatures of Post-Translational Modification