dbPTM

PEX5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PEX5_SCHPO
UniProt AC	O94325
Protein Name	Peroxisomal targeting signal receptor
Gene Name	pex5
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	598
Subcellular Localization	Cytoplasm. Peroxisome membrane Peripheral membrane protein. Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane (By similarity)..
Protein Description	Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import..
Protein Sequence	MSVEAGCSTLSNPLKKLTSTAVVNNSTPSAQYRKHLTKSQSRTYAPLQTLSEDQFTSFKNLQGNNSPLGNVVKNPVSLKTGNHTGTTTRGGSKENWVHSFSSLQQQNSKSAWTSEFSEVFLNSSENDRFRNLNQPLKQSFFGSAGLNLSSNTEIPLQSSLAIDETELAKKFEEASQISNKLEKEKDATGSKSIEELWEEHQKQLKNAGLEPASLEEYQKQWEDFLKSNNISDDPYTSSVNSFANDNLAHNKNIDPQIFQHSDTDNVVENSLQTEDVYSQNQDESSEVVKELNGIDPFVEAMNLIKNGGSISKAAVLLEQSVKENPQHFEAWKWLGRIHTLLGNESRVVEALLEAVKLDSTNLDLMMDLAVSYVNQSLNVQALVCLEDWIVNSFPQYRNRFAKINERFEEKDSANDLLKMQMYFLDVAYELSLAKKRSSKVQAGLGIIMYMLKEYERSADCFRQALQDEPSNEILWNKLGAALTNAEKNTEAVSSYNRAVSLQPQYVRVRSNMAVSNINLGYFEDAAKHLLAAIDIIQNSSTSMESCESNEELWEMLRKVFLIGFQSTDLASQSYPGANTSYIRAQLSDLQGWPGVELE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	NPLKKLTSTAVVNNS CHHHHHCCEEECCCC	25.46	25720772
29	Phosphorylation	VVNNSTPSAQYRKHL ECCCCCCCHHHHHHC	28.26	25720772
32	Phosphorylation	NSTPSAQYRKHLTKS CCCCCHHHHHHCCHH	22.73	25720772
66	Phosphorylation	KNLQGNNSPLGNVVK CCCCCCCCCCCCCCC	26.04	28889911
238	Phosphorylation	SDDPYTSSVNSFAND CCCCCCCHHHHHCCC	19.95	25720772
241	Phosphorylation	PYTSSVNSFANDNLA CCCCHHHHHCCCCCC	24.47	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PEX5_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PEX5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PEX5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of PEX5_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PEX5_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, AND MASSSPECTROMETRY.	18257517 [Abstract]