IF4E2_SCHPO - dbPTM
IF4E2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF4E2_SCHPO
UniProt AC O74743
Protein Name Eukaryotic translation initiation factor 4E-2
Gene Name tif452
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 243
Subcellular Localization
Protein Description Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures..
Protein Sequence MADAEDSRHSKNEGFPNTSLITEKLDLLDLFGSPKVKTEREGRPARLLEGLSAVNAETAFVKTHPLQHEWTLWFLKPPTQGLEWSDLLKEIISFKTVEEFWGIFKTISKASMLPAKSDYSYFLKGIRPEWEDPQNMNGGKWAYQSKHKGSNLDELWLYMVLAAIGETLDPTGKEVTGVVCNMRKGFYRIAVWTRNCNDKDVLEKIGLRFKEVLGISDKETIEYSAHEDSSKAGSMRAKTRMSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationKNEGFPNTSLITEKL
CCCCCCCHHHHHHHC		25.7524763107
19PhosphorylationNEGFPNTSLITEKLD
CCCCCCHHHHHHHCC		25.1421712547
33PhosphorylationDLLDLFGSPKVKTER
CHHHHHCCCCCCCCC		17.7624763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF4E2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF4E2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF4E2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DDB1_SCHPOddb1genetic
22681890
MPH1L_SCHPOmph1genetic
22681890
YOI5_SCHPOSPBC1778.05cgenetic
22681890
MGR2_SCHPOmgr2genetic
22681890
OXR1_SCHPOmug63genetic
22681890
GCN5_SCHPOgcn5genetic
22681890
RICTR_SCHPOste20genetic
22681890
MUG80_SCHPOmug80genetic
22681890
PSL1_SCHPOpsl1genetic
22681890
HUS1_SCHPOhus1genetic
22681890
PPK16_SCHPOppk16genetic
22681890
TBA2_SCHPOatb2genetic
22681890
PRS10_SCHPOrpt4genetic
22681890
SHF1_SCHPOshf1genetic
22681890
MCL1_SCHPOmcl1genetic
22681890
YJL4_SCHPOSPCC14G10.04physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF4E2_SCHPO

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Related Literatures of Post-Translational Modification

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