LAH1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAH1_SCHPO
• UniProt AC: P87058
• Protein Name: La protein homolog
• Gene Name: sla1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 298
• Subcellular Localization: Nucleus .
• Protein Description: Binds to the precursors of polymerase III RNAs. Functions in tRNA maturation..
• Protein Sequence: MSTEEQKEEIKDISSKQENSSEVPKAEEAGKVVESQKDTTSEEKKEETTEKKEDDGKKDLSFDEAEVLKQVEFYFSDTNLPHDKFLWTTSQKNDGWVPIQTIANFKRMRRFQPLEAIVNALRKSPELLEVDEAGEKVRRMIPLVRVDNKSVMERSVYCKGFGDEKDDTQIALEKFFEENAGPISAVRMRRDDDKKFKGSVFVEFKEPDVANKFLEKVKTAPLKWGEDELTIMSKKEYVDMKAELHKNDPPKFSSKRRRFDAFKEMDRQRPGKYSNRGRKFKKQRSSNASEEKPSAASE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTEEQKEE ------CCHHHHHHH	44.52	21712547
35	Phosphorylation	EAGKVVESQKDTTSE HHHHHEECCCCCCCH	30.81	27738172
61	Phosphorylation	DDGKKDLSFDEAEVL CCCCCCCCCCHHHHH	40.56	28889911
124	Phosphorylation	IVNALRKSPELLEVD HHHHHHHCHHHHEEC	19.71	28889911
285	Phosphorylation	RKFKKQRSSNASEEK HHHHCHHCCCCCCCC	26.00	21712547
286	Phosphorylation	KFKKQRSSNASEEKP HHHCHHCCCCCCCCC	38.31	25720772
289	Phosphorylation	KQRSSNASEEKPSAA CHHCCCCCCCCCCCC	51.00	21712547
294	Phosphorylation	NASEEKPSAASE--- CCCCCCCCCCCC---	47.75	21712547
297	Phosphorylation	EEKPSAASE------ CCCCCCCCC------	43.48	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAH1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAH1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAH1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAN1_SCHPO	ran1	physical	14665462
PCR1_SCHPO	pcr1	genetic	22160596
TOR1_SCHPO	tor1	genetic	22160596
TSC1_SCHPO	tsc1	genetic	22160596
XPOT_SCHPO	los1	genetic	22160596
RAN1_SCHPO	ran1	genetic	14665462

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61 AND SER-124, AND MASSSPECTROMETRY.
PubMed: 18257517