RAN1_SCHPO - dbPTM
RAN1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAN1_SCHPO
UniProt AC P08092
Protein Name Negative regulator of sexual conjugation and meiosis
Gene Name ran1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 470
Subcellular Localization
Protein Description This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place..
Protein Sequence MMRENPELLLGQVLGDSLRFVSIIGAGAYGVVYKAEDIYDGTLYAVKALCKDGLNEKQKKLQARELALHARVSSHPYIITLHRVLETEDAIYVVLQYCPNGDLFTYITEKKVYQGNSHLIKTVFLQLISAVEHCHSVGIYHRDLKPENIMVGNDVNTVYLADFGLATTEPYSSDFGCGSLFYMSPECQREVKKLSSLSDMLPVTPEPIESQSSSFATAPNDVWALGIILINLCCKRNPWKRACSQTDGTYRSYVHNPSTLLSILPISRELNSLLNRIFDRNPKTRITLPELSTLVSNCKNLTRRLRPAPLVSSRYLAYQQQQQQQQMNLQQGIQGYPHQGYMPTQNIGFPWPPTPQFVSNWNHCATPTIPVSLQVLTPNSSLKVDPTTPLTAPIHATESFWPSAAAAAAAVHNNANSYMPITPTPYPNNAKIFGYPNQPPLTPIPFTGFVLHPAPVGRAADAVDPSRKSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
469PhosphorylationAVDPSRKSL------
CCCCCCCCC------
37.9028889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAN1_SCHPO !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAN1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAN1_SCHPO !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC11_SCHPOcdc11genetic
16787941
SPG1_SCHPOspg1genetic
16787941
SID1_SCHPOsid1genetic
16787941
KAPR_SCHPOcgs1genetic
1657594
REC8_SCHPOrec8genetic
12727894
SPO11_SCHPOrec12genetic
12727894
RAD24_SCHPOrad24genetic
11818066
RES1_SCHPOres1genetic
11781565
RAD1_SCHPOrad1genetic
10521402
CDS1_SCHPOcds1genetic
10521402
STE11_SCHPOste11genetic
3185514
RES1_SCHPOres1genetic
7909513
RES2_SCHPOres2genetic
7909513
TOR2_SCHPOtor2genetic
17046992
GBLP_SCHPOcpc2physical
10805744
MEI2_SCHPOmei2physical
10835379
STE11_SCHPOste11physical
8945514
MEI2_SCHPOmei2physical
9062192
PUC1_SCHPOpuc1genetic
8006074
NRD1_SCHPOnrd1genetic
21409593
CTK1_SCHPOlsk1genetic
22144909
MEI2_SCHPOmei2genetic
22144909
CID14_SCHPOcid14genetic
16478992
DIS3_SCHPOdis3genetic
16478992
MEI2_SCHPOmei2genetic
1657594
WIS1_SCHPOwis1genetic
8832415
CG22_SCHPOcig2genetic
7909513
PUC1_SCHPOpuc1genetic
7909513
CDC10_SCHPOcdc10genetic
7909513
ATF1_SCHPOatf1genetic
8824587
HOG1_SCHPOsty1genetic
8824587
RAD3_SCHPOrad3genetic
10521402
RAD9_SCHPOrad9genetic
10521402
RAD17_SCHPOrad17genetic
10521402
HUS1_SCHPOhus1genetic
10521402
MIK1_SCHPOmik1genetic
10521402
WEE1_SCHPOwee1genetic
10521402
PAC1_SCHPOpac1genetic
1989884
PAC1_SCHPOpac1genetic
7616961
MIP1_SCHPOmip1genetic
10648609
RAN1_SCHPOran1physical
26771498
PVG4_SCHPOmbx2physical
26771498
HAP5_SCHPOphp5physical
26771498
YHK6_SCHPOSPBC660.06physical
26771498
RSV1_SCHPOrsv1physical
26771498
YC8F_SCHPOSPCC622.15cphysical
26771498
PIL1_SCHPOpil1physical
26771498
SFR1_SCHPOsfr1genetic
25864229

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAN1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, AND MASSSPECTROMETRY.

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