dbPTM

RAN1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAN1_SCHPO
UniProt AC	P08092
Protein Name	Negative regulator of sexual conjugation and meiosis
Gene Name	ran1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	470
Subcellular Localization
Protein Description	This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place..
Protein Sequence	MMRENPELLLGQVLGDSLRFVSIIGAGAYGVVYKAEDIYDGTLYAVKALCKDGLNEKQKKLQARELALHARVSSHPYIITLHRVLETEDAIYVVLQYCPNGDLFTYITEKKVYQGNSHLIKTVFLQLISAVEHCHSVGIYHRDLKPENIMVGNDVNTVYLADFGLATTEPYSSDFGCGSLFYMSPECQREVKKLSSLSDMLPVTPEPIESQSSSFATAPNDVWALGIILINLCCKRNPWKRACSQTDGTYRSYVHNPSTLLSILPISRELNSLLNRIFDRNPKTRITLPELSTLVSNCKNLTRRLRPAPLVSSRYLAYQQQQQQQQMNLQQGIQGYPHQGYMPTQNIGFPWPPTPQFVSNWNHCATPTIPVSLQVLTPNSSLKVDPTTPLTAPIHATESFWPSAAAAAAAVHNNANSYMPITPTPYPNNAKIFGYPNQPPLTPIPFTGFVLHPAPVGRAADAVDPSRKSL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
469	Phosphorylation	AVDPSRKSL------ CCCCCCCCC------	37.90	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAN1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAN1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAN1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC11_SCHPO	cdc11	genetic	16787941
SPG1_SCHPO	spg1	genetic	16787941
SID1_SCHPO	sid1	genetic	16787941
KAPR_SCHPO	cgs1	genetic	1657594
REC8_SCHPO	rec8	genetic	12727894
SPO11_SCHPO	rec12	genetic	12727894
RAD24_SCHPO	rad24	genetic	11818066
RES1_SCHPO	res1	genetic	11781565
RAD1_SCHPO	rad1	genetic	10521402
CDS1_SCHPO	cds1	genetic	10521402
STE11_SCHPO	ste11	genetic	3185514
RES1_SCHPO	res1	genetic	7909513
RES2_SCHPO	res2	genetic	7909513
TOR2_SCHPO	tor2	genetic	17046992
GBLP_SCHPO	cpc2	physical	10805744
MEI2_SCHPO	mei2	physical	10835379
STE11_SCHPO	ste11	physical	8945514
MEI2_SCHPO	mei2	physical	9062192
PUC1_SCHPO	puc1	genetic	8006074
NRD1_SCHPO	nrd1	genetic	21409593
CTK1_SCHPO	lsk1	genetic	22144909
MEI2_SCHPO	mei2	genetic	22144909
CID14_SCHPO	cid14	genetic	16478992
DIS3_SCHPO	dis3	genetic	16478992
MEI2_SCHPO	mei2	genetic	1657594
WIS1_SCHPO	wis1	genetic	8832415
CG22_SCHPO	cig2	genetic	7909513
PUC1_SCHPO	puc1	genetic	7909513
CDC10_SCHPO	cdc10	genetic	7909513
ATF1_SCHPO	atf1	genetic	8824587
HOG1_SCHPO	sty1	genetic	8824587
RAD3_SCHPO	rad3	genetic	10521402
RAD9_SCHPO	rad9	genetic	10521402
RAD17_SCHPO	rad17	genetic	10521402
HUS1_SCHPO	hus1	genetic	10521402
MIK1_SCHPO	mik1	genetic	10521402
WEE1_SCHPO	wee1	genetic	10521402
PAC1_SCHPO	pac1	genetic	1989884
PAC1_SCHPO	pac1	genetic	7616961
MIP1_SCHPO	mip1	genetic	10648609
RAN1_SCHPO	ran1	physical	26771498
PVG4_SCHPO	mbx2	physical	26771498
HAP5_SCHPO	php5	physical	26771498
YHK6_SCHPO	SPBC660.06	physical	26771498
RSV1_SCHPO	rsv1	physical	26771498
YC8F_SCHPO	SPCC622.15c	physical	26771498
PIL1_SCHPO	pil1	physical	26771498
SFR1_SCHPO	sfr1	genetic	25864229

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAN1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-469, AND MASSSPECTROMETRY.	18257517 [Abstract]