GBLP_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBLP_SCHPO
• UniProt AC: Q10281
• Protein Name: Guanine nucleotide-binding protein subunit beta-like protein
• Gene Name: rkp1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 314
• Subcellular Localization: Membrane . Associated with particulate fractions.
• Protein Description: May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis..
• Protein Sequence: MPEQLVLRATLEGHSGWVTSLSTAPENPDILLSGSRDKSIILWNLVRDDVNYGVAQRRLTGHSHFVSDCALSFDSHYALSASWDKTIRLWDLEKGECTHQFVGHTSDVLSVSISPDNRQVVSGSRDKTIKIWNIIGNCKYTITDGGHSDWVSCVRFSPNPDNLTFVSAGWDKAVKVWDLETFSLRTSHYGHTGYVSAVTISPDGSLCASGGRDGTLMLWDLNESTHLYSLEAKANINALVFSPNRYWLCAATGSSIRIFDLETQEKVDELTVDFVGVGKKSSEPECISLTWSPDGQTLFSGWTDNLIRVWQVTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EQLVLRATLEGHSGW CEEEEEEEEECCCCE	20.93	28889911
39	Phosphorylation	LSGSRDKSIILWNLV ECCCCCCEEEEEEEH	21.10	28889911
52	Phosphorylation	LVRDDVNYGVAQRRL EHHCCCCHHHHHHHH	16.90	28889911
148	Phosphorylation	TITDGGHSDWVSCVR EEECCCCCCCEEEEE	36.12	28889911
157	Phosphorylation	WVSCVRFSPNPDNLT CEEEEEECCCCCCEE	17.13	28889911
181	Phosphorylation	VKVWDLETFSLRTSH EEEEEEECEEEECCC	26.31	25720772
183	Phosphorylation	VWDLETFSLRTSHYG EEEEECEEEECCCCC	25.10	28889911
242	Phosphorylation	NINALVFSPNRYWLC CCCEEEECCCCEEEE	17.49	28889911
255	Phosphorylation	LCAATGSSIRIFDLE EEEECCCEEEEEECC	19.75	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBLP_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBLP_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBLP_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAN1_SCHPO	ran1	genetic	10805744
PCK2_SCHPO	pck2	genetic	11263963
NRD1_SCHPO	nrd1	physical	15277777
RAN1_SCHPO	ran1	physical	10805744
PCK2_SCHPO	pck2	physical	11263963
E2AK2_SCHPO	hri2	genetic	23671279

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; SER-39; TYR-52;SER-148; SER-242 AND SER-255, AND MASS SPECTROMETRY.
PubMed: 18257517