NRD1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRD1_SCHPO
• UniProt AC: Q09702
• Protein Name: Negative regulator of differentiation 1
• Gene Name: nrd1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 529
• Protein Description: Negative regulator of sexual differentiation. Acts by repressing the transcription of meiosis-inducing, ste11-regulated genes until cells reach a critical level of starvation. RNA-binding protein that preferentially binds poly(U)..
• Protein Sequence: MSSSSPSSQSRLSVPGRTPHLPPLTIPHTVSAEGLATPNTPHALLPTGLLMGSPFVQSPTSYTSMHGLPFSTTQMAAAPAHPTTGYNVSRVTSPNVANFAPGYFPLPNNTTQPVKTVYVGNLPPNTPIDEILSCVRTGPIESAWILPEKNCAFISFLDPSHATAFFQDAALKRLTIRGTEVKVGWGKNSASNSSVLLAVQQSGACRNVFLGNLPNGITEDEIREDLEPFGPIDQIKIVTERNIAFVHFLNIAAAIKAVQELPLNPKWSKRRIYYGRDRCAVGLKQPAYFSKGQVGVVGGYPVMGYPPPSPVLQKPDLIMTGNRTVYIGNIHADTTIEEICNAVRGGLLHNIRYLQEKHICFVTFVDPVSAFRFFEMSNIHGLVIRNRRLKIGWGKHSGPLPSNIALAVAGGASRNIYIGNADDSLTIERLKEDFEEFGEIEYVNFFREKNCAFVNFTSLASAINAIDRIKQKKGYENYRISYGKDRCGNPPRTNSKSDVLSVSSDMSMPVDLVVPQQGISGFMPTNSNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MSSSSPSSQSRLSVP CCCCCCCCCCCCCCC	35.24	29996109
13	Phosphorylation	PSSQSRLSVPGRTPH CCCCCCCCCCCCCCC	25.75	29996109
92	Phosphorylation	GYNVSRVTSPNVANF CCCCCCCCCCCCCCC	37.04	29996109
93	Phosphorylation	YNVSRVTSPNVANFA CCCCCCCCCCCCCCC	16.18	28889911
309	Phosphorylation	VMGYPPPSPVLQKPD CCCCCCCCCCCCCCC	33.15	29996109
320	Phosphorylation	QKPDLIMTGNRTVYI CCCCEEEECCCEEEE	25.06	29996109
501	Phosphorylation	NSKSDVLSVSSDMSM CCCCCCEEECCCCCC	21.57	25720772
503	Phosphorylation	KSDVLSVSSDMSMPV CCCCEEECCCCCCCE	19.76	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRD1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRD1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRD1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MSA1_SCHPO	msa1	genetic	15166138
GBLP_SCHPO	cpc2	physical	15277777
CGP1_SCHPO	pas1	genetic	10982385
GBLP_SCHPO	cpc2	physical	22276125

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-93, AND MASSSPECTROMETRY.
PubMed: 18257517