PIL1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PIL1_SCHPO
• UniProt AC: O74960
• Protein Name: Probable sphingolipid long chain base-responsive protein pil1
• Gene Name: pil1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 351
• Protein Description: Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity)..
• Protein Sequence: MMNRAYSLRNSRAPTASQLLNPPPPSSSTRSGRLFAPLSHTMRINHAATFTPDLAKRLAVLVKMEKNVMRSMEVTIRGRRDCARQLSYWGEDCDDDISDVTDKLGVLFYEMAELENYLIDRYDQYRMTLKSIRNIESSVQPSREKKQKLLDQIYALKHKDPESPRLVTMEQELVREEAACLVAEAQLSNTTREKFKQAMTFNLDALHEHAEKLNLIATYGRHLLNLIDDTPVTPGEARPAYDGYETSRQIVMDAEHALSSWVPSQPAVNFVKPQIEDDAQSDARSWNEYEAQGEPVPVEQVTHLQDDVQSDTSEIIENEPGMHPHVHAERMSRIASESSDAVPQQTAVQVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MMNRAYSLRNSRA --CCCHHHHCCCCCC		25720772
7	Phosphorylation	-MMNRAYSLRNSRAP -CCCHHHHCCCCCCC		29996109
11	Phosphorylation	RAYSLRNSRAPTASQ HHHHCCCCCCCCHHH		28889911
15	Phosphorylation	LRNSRAPTASQLLNP CCCCCCCCHHHHCCC		28889911
17	Phosphorylation	NSRAPTASQLLNPPP CCCCCCHHHHCCCCC		28889911
26	Phosphorylation	LLNPPPPSSSTRSGR HCCCCCCCCCCCCCE		29996109
27	Phosphorylation	LNPPPPSSSTRSGRL CCCCCCCCCCCCCEE		25720772
28	Phosphorylation	NPPPPSSSTRSGRLF CCCCCCCCCCCCEEE		29996109
29	Phosphorylation	PPPPSSSTRSGRLFA CCCCCCCCCCCEEEE		28889911
31	Phosphorylation	PPSSSTRSGRLFAPL CCCCCCCCCEEEEEC		25720772
39	Phosphorylation	GRLFAPLSHTMRINH CEEEEECCCCEECCC		28889911
41	Phosphorylation	LFAPLSHTMRINHAA EEEECCCCEECCCCH		25720772
131	Phosphorylation	QYRMTLKSIRNIESS HHHHHHHHHHHCHHH		21712547
137	Phosphorylation	KSIRNIESSVQPSRE HHHHHCHHHCCCCHH		21712547
163	Phosphorylation	LKHKDPESPRLVTME HHCCCCCCCCCEEHH		-
230	Phosphorylation	LLNLIDDTPVTPGEA HHHHCCCCCCCCCCC		28889911
233	Phosphorylation	LIDDTPVTPGEARPA HCCCCCCCCCCCCCC		28889911
246	Phosphorylation	PAYDGYETSRQIVMD CCCCCCHHHHHHHHC		29996109
247	Phosphorylation	AYDGYETSRQIVMDA CCCCCHHHHHHHHCH		29996109
264	Phosphorylation	ALSSWVPSQPAVNFV HHHHCCCCCCCCCCC		29996109
281	Phosphorylation	QIEDDAQSDARSWNE CCCCCHHHCHHCHHH		29996109
332	Phosphorylation	HVHAERMSRIASESS CCCHHHHHHHHHCCC		25720772
336	Phosphorylation	ERMSRIASESSDAVP HHHHHHHHCCCCCCC		25720772
338	Phosphorylation	MSRIASESSDAVPQQ HHHHHHCCCCCCCCC		29996109
339	Phosphorylation	SRIASESSDAVPQQT HHHHHCCCCCCCCCC		29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PIL1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PIL1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PIL1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIL1_SCHPO	pil1	physical	21900489
PIL1_SCHPO	pil1	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.