GAR2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GAR2_SCHPO
• UniProt AC: P41891
• Protein Name: Protein gar2
• Gene Name: gar2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 500
• Subcellular Localization: Nucleus, nucleolus.
• Protein Description: Helps the assembly of pre-ribosomal particles containing 18S rRNA..
• Protein Sequence: MAKKDKTSVKKSVKETASKKGAIEKPSKSKKITKEAAKEIAKQSSKTDVSPKKSKKEAKRASSPEPSKKSVKKQKKSKKKEESSSESESESSSSESESSSSESESSSSESESSSSESSSSESEEEVIVKTEEKKESSSESSSSSESEEEEEAVVKIEEKKESSSDSSSESSSSESESESSSSESEEEEEVVEKTEEKKEGSSESSSDSESSSDSSSESGDSDSSSDSESESSSEDEKKRKAEPASEERPAKITKPSQDSNETCTVFVGRLSWNVDDQWLGQEFEEYGTIVGARVIMDGQSGRSKGYGYVDFETPEAAKAAVAANGTKEIDGRMVNLDLSNPRPANPQPYAQQRAGNFGDQLSEPSDTVFVGNLSFNATEDDLSTAFGGCGDIQSIRLPTDPQSGRLKGFGYVTFSDIDSAKKCVEMNGHFIAGRPCRLDFSTPRTGGGSRGGRGGFGGRGGFGGRGGFGGGRGRGRGGARSGNPNRGSVAPFSGNKVTFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	KEIAKQSSKTDVSPK HHHHHHHCCCCCCCC	36.76	21712547
47	Phosphorylation	IAKQSSKTDVSPKKS HHHHHCCCCCCCCHH	43.51	21712547
50	Phosphorylation	QSSKTDVSPKKSKKE HHCCCCCCCCHHHHH	33.54	24763107
62	Phosphorylation	KKEAKRASSPEPSKK HHHHHHCCCCCCCHH	50.92	24763107
63	Phosphorylation	KEAKRASSPEPSKKS HHHHHCCCCCCCHHH	32.09	21712547
67	Phosphorylation	RASSPEPSKKSVKKQ HCCCCCCCHHHHHHH	51.56	21712547
143	Phosphorylation	SSSESSSSSESEEEE CCCCCCCCCCCHHHH	39.82	28889911
144	Phosphorylation	SSESSSSSESEEEEE CCCCCCCCCCHHHHH	47.27	28889911
146	Phosphorylation	ESSSSSESEEEEEAV CCCCCCCCHHHHHHH	52.86	28889911
245	Phosphorylation	KRKAEPASEERPAKI HHCCCCCCCCCCCCC	51.19	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
50	S	Phosphorylation	Kinase	CDK1	P04551	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GAR2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GAR2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CID14_SCHPO	cid14	physical	16478992

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-144 ANDSER-146, AND MASS SPECTROMETRY.
PubMed: 18257517