RAD25_SCHPO - dbPTM
RAD25_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD25_SCHPO
UniProt AC P42657
Protein Name DNA damage checkpoint protein rad25
Gene Name rad25
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 270
Subcellular Localization
Protein Description Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted..
Protein Sequence MSNSRENSVYLAKLAEQAERYEEMVENMKKVACSNDKLSVEERNLLSVAYKNIIGARRASWRIISSIEQKEESRGNTRQAALIKEYRKKIEDELSDICHDVLSVLEKHLIPAATTGESKVFYYKMKGDYYRYLAEFTVGEVCKEAADSSLEAYKAASDIAVAELPPTDPMRLGLALNFSVFYYEILDSPESACHLAKQVFDEAISELDSLSEESYKDSTLIMQLLRDNLTLWTSDAEYNQSAKEEAPAAAAASENEHPEPKESTTDTVKA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNSRENSV
------CCCCHHHHH		43.4421712547
4Phosphorylation----MSNSRENSVYL
----CCCCHHHHHHH		33.3924763107
8PhosphorylationMSNSRENSVYLAKLA
CCCCHHHHHHHHHHH		13.8521712547
47PhosphorylationVEERNLLSVAYKNII
HHHHHHHHHHHHHHH		14.1025720772
50PhosphorylationRNLLSVAYKNIIGAR
HHHHHHHHHHHHHHH		11.4725720772
115PhosphorylationHLIPAATTGESKVFY
HCCCCCCCCCCEEEE		33.9425720772
205PhosphorylationQVFDEAISELDSLSE
HHHHHHHHHHHHCCH		38.8724763107
209PhosphorylationEAISELDSLSEESYK
HHHHHHHHCCHHHHC		46.5521712547
211PhosphorylationISELDSLSEESYKDS
HHHHHHCCHHHHCHH		43.1829996109
214PhosphorylationLDSLSEESYKDSTLI
HHHCCHHHHCHHHHH		33.1721712547
215PhosphorylationDSLSEESYKDSTLIM
HHCCHHHHCHHHHHH		23.3021712547
233PhosphorylationRDNLTLWTSDAEYNQ
HHCCEEECCCHHHCH		21.6029996109
234PhosphorylationDNLTLWTSDAEYNQS
HCCEEECCCHHHCHH		24.2028889911
238PhosphorylationLWTSDAEYNQSAKEE
EECCCHHHCHHHHHH		21.8821712547
241PhosphorylationSDAEYNQSAKEEAPA
CCHHHCHHHHHHHHH		37.3628889911
253PhosphorylationAPAAAAASENEHPEP
HHHHHHHHCCCCCCC		35.9128889911
263PhosphorylationEHPEPKESTTDTVKA
CCCCCCCCCCCCCCC		42.6129996109
264PhosphorylationHPEPKESTTDTVKA-
CCCCCCCCCCCCCC-		29.7724763107
265PhosphorylationPEPKESTTDTVKA--
CCCCCCCCCCCCC--		38.6621712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD25_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD25_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD25_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAD24_SCHPOrad24physical
12242289
CHK1_SCHPOchk1physical
10090724
MPIP_SCHPOcdc25physical
10090724
AGO1_SCHPOago1physical
17043360
DAD1_SCHPOdad1genetic
18931302
PST2_SCHPOpst2genetic
19547744
YLO2_SCHPOtma23genetic
18818364
ROK1_SCHPOrok1genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
ASK1_SCHPOask1genetic
18818364
HIR1_SCHPOhip1genetic
18818364
SET1_SCHPOset1genetic
18818364
SPP1_SCHPOspf1genetic
18818364
PRZ1_SCHPOprz1genetic
22496451
RST2_SCHPOrst2genetic
22496451
PRZ1_SCHPOprz1physical
22496451
RAD24_SCHPOrad24genetic
22496451
HSP9_SCHPOhsp9genetic
22182414
MPIP_SCHPOcdc25physical
22182414
SDS23_SCHPOsds23genetic
22681890
ALY1_SCHPOSPBC839.02genetic
22681890
NUP60_SCHPOnup60genetic
22681890
APT_SCHPOapt1genetic
22681890
GIT3_SCHPOgit3genetic
22681890
NCPR_SCHPOccr1genetic
22681890
FSV1_SCHPOfsv1genetic
22681890
SKI2_SCHPOSPCC550.03cgenetic
22681890
YB22_SCHPOSPBC31F10.02genetic
22681890
ELP1_SCHPOelp1genetic
22681890
PDS5_SCHPOpds5genetic
22681890
CTK3_SCHPOlsg1genetic
22681890
EME1_SCHPOeme1genetic
22681890
GLD1_SCHPOgld1genetic
22681890
SAT1_SCHPOsat1genetic
22681890
SHF1_SCHPOshf1genetic
22681890
PRZ1_SCHPOprz1genetic
22681890
RF1M_SCHPOmrf1genetic
22681890
BYR2_SCHPObyr2physical
12242289
SSP1_SCHPOssp1physical
24451546
RAD25_SCHPOrad25physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD25_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-234 AND SER-253, ANDMASS SPECTROMETRY.

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